急性甲胺磷中毒大鼠肌肉乙酰胆碱含量与肌无力关系的研究  

Experimental study on the relations acetylcholine and myasthenia in acute methamidphos intoxicated rats

作　　者：叶红卫[1] 彭广军[1] 贾雪梅[1] 田英平[2] 石汉文[2] 

机构地区：[1]河北大学附属医院急诊科,071000 [2]河北医科大学第二附属医院急诊科

出　　处：《当代医学》2009年第3期37-39,共3页Contemporary Medicine

摘　　要：目的研究Ach的代谢在IMS发生过程中所起的作用,以探讨IMS的发病机理。方法在用甲胺磷染毒制作肌无力模型,用碱性羟胺比色法测量其隔肌和腓肠肌Ach含量。结果实验一大鼠甲胺磷染毒后12h、24h肌肉乙酰胆碱含量明显低于正常对照组,实验二低肌力组大鼠腓肠肌Ach含量明显低于高肌力组大鼠腓肠肌Ach,两者含量有显著性差异。结论大鼠急性甲胺磷中毒时,肌肉的Ach含量有一过性下降。神经末梢Ach含量下降有可能造成在神经冲动到达时,神经末档释放Ach减少,从而导致肌无力的出现。Objective To study the mechanism of myasthenia following acute organophate poisinong.Methods Adult SD rats were made by injection of methamidophos,the acetylcholine levels in blood and museule were measured by using basic hydroxylamine chomatmetry. Results The control group has significant difference of the acetycholine levels with the poisoned group of the 12th hour group and the poisoned group of the 24th hour group.Conclusion The actylcholine levels in lateral gastrocnemius muscles of acute methmidphos intoxicated rats possibly play an inportant role in myasthenia rats.

关 键 词：乙酰胆碱 隔肌 腓肠肌 甲胺磷 肌无力 

分 类 号：R595.4[医药卫生—内科学] R285.5[医药卫生—临床医学]