^99Tc^m-depreotide生长抑素受体显像在肺癌诊断中的应用  

^99Tc^m-depreotide somatostatin receptor imaging in diagnosis of lung cancer

作　　者：邢加强[1] 杨国仁[2] 张百江[1] 胡旭东[3] 霍宗伟[3] 宋平平[1] 

机构地区：[1]山东省肿瘤医院胸外科,济南250117 [2]山东省肿瘤医院PET-CT中心,济南250117 [3]山东省肿瘤医院核医学科,济南250117

出　　处：《中华核医学杂志》2009年第1期31-33,共3页Chinese Journal of Nuclear Medicine

基　　金：山东省卫生厅科技基金（2005HW132）

摘　　要：目的探讨^99Tc^m-地普奥肽（depreotide）生长抑素受体显像对肺癌的诊断价值。方法52例肺部肿瘤患者[小细胞肺癌（SCLC）8例，非小细胞肺癌（NSCLC）38例，良性结节6例]静脉注射^99Tc^m-depreotide（740±60）MBq后行平面及胸部SPECT显像，并勾画感兴趣区（ROI），计算肿瘤和对侧正常肺组织的放射性（T／N）比值，所有病灶均经病理检查证实。采用SPSS 11.5软件，行两样本t检验。结果^99Tc^m-depreotide显像诊断52例肺癌的灵敏度、特异性、准确性分别为93．5％（43／46）、5／6和92．3％（48／52）；假阴性3例，假阳性1例。3例假阴性分别为2例鳞癌、1例腺癌，1例假阳性为炎性假瘤。SCLC和NSCLC组T／N比值分别为1．948±0．282和1．280±0．160。SCLC对^99Tc^m-depreotide的摄取明显高于NSCLC（t=0．130，P〈0．05）。结论^99Tc^m-depreotide生长抑素受体显像是一种无创、安全、有效、简便的检查方法，对肺癌尤其是SCLC有良好的诊断价值。Objective The high expression of somatostatin receptor in various tumor cells provides the molecular basis for using radiolabeled somatostatin analogs as tumor tracers. Research of somatostatin analogs scintigraphy in both small cell lung cancer （SCLC） and non-small cell lung cancer （NSCLC） have also been reported. The purpose of this study was to investigate the clinical efficacy of ^99Tc^m-depreotide, a new somatostatin analog, in the diagnosis of lung cancer. Methods The subjects included 52 consecutive patients, with 8 SCLC, 38 NSCLC and 6 benign lung lesions. Histopathological results were obtained in all cases. Planar images of neck and chest were obtained at 4-6 h after injection of ^99Tc^m-depreotide [ （740±60） MBq] and then chest SPECT was performed. The radioactivity ratio of tumor to normal tissue （T/N） was calculated and used as semi-quantitative evaluation. All scintigraphically detected lesions were compared with the findings of other imaging modalities and histopathological results. Tile data were statistically analyzed with SPSS 11.5. Results The sensitivity, specificity and accuracy for ^99Tc^m-depreotide imaging in differentiating malig- nant from benign lesions were 93.5% （43/46） , 5/6 and 92.3% （48/52）. Three false negative cases included two squamous cell carcinomas and one adenocarcinoama. One false positive case was an inflammatory pseudotumor. The T/N ratio in SCLC was significantly higher than that in NSCLC （1. 948±0. 282 vs 1. 280 ± 0. 160, t =0. 130, P 〈 0.05 ）. Conclusion With the effectiveness, availability and low cost, ^99Tc^m-depreotide scintigraphy may be a promising imaging method for detection of both SCLC and NSCLC.

关 键 词：肺肿瘤 受体 生长抑素 体层摄影术 发射型计算机 单光子 Depreotide 

分 类 号：R686[医药卫生—骨科学]