丙泊酚复合小剂量米非司酮、米索前列醇用于人工流产的效果观察  

Effect Observation of Propofol Combined with Small Dose of Mifepristone and Misoprostol in Artificial Abortion

作　　者：林小玲[1] 黄波[1] 刘安林[1] 姚虹[1] 陈爱文[1] 

机构地区：[1]广州医学院附属深圳沙井医院麻醉科

出　　处：《医学综述》2009年第4期636-637,共2页Medical Recapitulate

摘　　要：目的观察丙泊酚复合较小剂量米非司酮、米索前列醇无痛人工流产术的效果。方法80例孕5～10周的未产妇，随机分为研究组和对照组，每组40例。两组术前均肌内注射曲马多100mg和阿托品0．5mg，以4～6mg／s的速度静脉注射丙泊酚，至睫毛反射消失后行手术，术中视患者反应追加丙泊酚20～30mg。研究组术前24～48h服用米非司酮50mg，手术前1h服用米索前列醇200μg，对照组未服用任何药物。记录两组丙泊酚的总用量、手术时间、术毕苏醒时间、宫颈松弛度。结果研究组丙泊酚总用量、手术时间、术毕苏醒时间明显低于对照组，差异有统计学意义（P〈0．05）。研究组宫颈松弛度有效率与对照组比较有显著差异（P〈0．05）。结论术前小剂量米非司酮和米索前列醇可减少无痛人工流产术丙泊酚用量，镇痛良好，手术时间短，苏醒快。Objective To observe the effect of propofol combined with small dose of mifepristone and misoprostol in artificial abortion. Methods 80 young nullipara pregnant for 5 - 10 weeks were randomly divied into control group and research group, each group has 40 cases. Two groups have intramuscular injection tramadol 100 mg and atropine 0. 5 mg, have 4 - 6 mg/s velocity to intravenous injection propofol, operate after the disappearance oflash reflex. Add propofo120 - 30mg depending on patients response. Research group take mifepristone 50 mg 24 - 48 h preoperation, and take misoprostol 200 μg one hour before surgery, control group take no medicine. Record the total propofol dose, operation time, wake time after operatinoperation, cervix relaxation degree. Results Total propofol dose,operation time and wake time after operation in research group were significantly lower than in control group（ P 〈0.05 ）. Effective rate of cervix relaxation degree in research group was significantly higher than in control group. Conclusion When used in preoperation propofol combined small dose mifepristone and misoprostol can reduce propofol dosage in the anodynia induced abortion, have in good analgesia, short operation time and quick palinesthesia.

关 键 词：丙泊酚 米非司酮 米索前列醇 人工流产 全身麻醉 

分 类 号：R719.3[医药卫生—妇产科学]