Ⅱ型糖尿病动物模型的研究进展  

Progress on Animal Models for Non-insulin-dependent Diabetes Mellitus

作　　者：李娜[1] 曲卉[1] 曹宇立[1] 张周[1] 

机构地区：[1]中国科学院上海药物研究所,上海201203

出　　处：《实验动物与比较医学》2009年第1期66-70,共5页Laboratory Animal and Comparative Medicine

摘　　要：人类糖尿病是一个复杂的代谢性疾病，尤其是Ⅱ型糖尿病。而合适的糖尿病动物模型则是糖尿病研究的重要基础，Ⅱ型糖尿病动物模型主要分为实验性糖尿病动物模型、自发性糖尿病动物模型、转基因糖尿病动物模型和胰岛素抵抗的细胞模型等。文章主要从糖尿病动物模型的发病机理和临床表现出发，对各种模型的研究进展作一综述，并展望其前景。Human diabetic mellitus is the complicated metabolic disease, especially of non-insulindependent diabetes mellitus （NIDDM）. Then the appropriate diabetic mellitus animal model is the important basic of research. There are many NIDDM animal models, such as experimental NIDDM animal model, spontaneous NIDDM animal model, transgenic NIDDM animal model and anti-insulin cell model for NIDDM, and so on. This mini-review mainly focused on the advances of the animal models, which from the pathogenesis and clinic symptom,and also the prospect was indicated.

关 键 词：Ⅱ型糖尿病 动物模型 进展 

分 类 号：R587.1[医药卫生—内分泌] R-332[医药卫生—内科学]