不同剂量阿托伐他汀对急性心梗PCI术后患者CRP,IL-6及TNF-α的影响  

Effects of different doses of Atorvastatin on CRP,IL-6 and TNF-α in patients with acute myocardial infarction undergoing percutaneous coronary intervention

作　　者：林玲[1] 壮可[1] 万颖[2] 李红[3] 李裕[3] 赵燕[1] 张宏[1] 

机构地区：[1]云南省第一人民医院心内科,云南昆明650032 [2]云南省第一人民医院内干科,云南昆明650032 [3]云南省第一人民医院检验科,云南昆明650032

出　　处：《云南医药》2009年第1期22-24,共3页Medicine and Pharmacy of Yunnan

摘　　要：目的比较不同剂量阿托伐他汀对血脂正常急性心梗PCI术后患者C-反应蛋白、白细胞介素-6及肿瘤坏死因子-α水平的影响。方法入选127例单支血管完全闭塞PCI术后患者,分为A组42例、B组44例、C组41例,给予阿托伐他汀片A组20mg1次/d;B组40mg1次/d;C组80mg1次/d;用药前及用药后1周、2周及4周分别测定C-反应蛋白、血细胞介素-6及肿瘤坏死因子-α水平。结果用药后C-反应蛋白、白细胞介素-6及肿瘤坏死因子-α水平B组较A组明显降低(P<0.05),C组又较B组明显降低(P<0.05)。3组降低血清低密度脂蛋白胆固醇与总胆固醇作用相似(P>0.05)。结论阿托伐他汀能降低血脂正常急性心梗PCI术后患者C-反应蛋白、血细胞介素-6及肿瘤坏死因子-α水平,且呈剂量依赖性。Objective To investigate the effects of different doses of Atorvastatin on C reactive protein（CRP）, IL-6 and tumor necrosis factor-α（TNF-α）in patients of acute myocardial infarction （AMI） with normal serum lipid treated with percutaneous coronary intervention （PCI）. Methods 127 patients of AMI with normal serum lipid received PCI were randomizely divided into A group（n = 42, 20rag qd）, B group （n = 44, 40mg qd） and C group （n = 41,80mg qd） . CRP, IL-6 and TNF-α were measured after 1 week, 2 weeks and 4 weeks. Results After treatment, the levels of CRP, IL-6 and TNF-α were lowered in B group compared with A group（ P 〈 0.05 ）, while its were lowest in C group （P 〈 0.05 ）. The effects of Atorvastatin on modifying LDL and total cholesterol were not different significantly （P 〉 0.05）. Conclusion Atorvastatin can decrease the levels of CRP, IL-6 and TNF-α in patients of AMI with normal serum lipid.

关 键 词：急性心梗 PCI术后 炎性细胞因子 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]