兰索拉唑的合成工艺改进  

Improved synthesis of lansoprazole

作　　者：王庆河[1] 沙宇[1] 王晋芳[1] 富曰[1] 程卯生[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2009年第1期42-44,共3页Chinese Journal of Medicinal Chemistry

摘　　要：目的改进兰索拉唑的合成工艺。方法以2,3-二甲基吡啶为起始原料,经4步反应合成目标化合物。结果与结论目标物的总收率由文献的12.7%提高到21.2%,其结构经熔点、质谱和1H-NMR谱测试确证。改进后的合成方法较原工艺路线缩短,易于工业化生产。Aim To improve synthetic process of lansoprazole. Methods The target compound was prepared through a four-step reaction from 2,3-dimethylpyridine. Results and conclusion Its structure was confirmed by mp,MS,and ^1H-NMR. The total yield was raised from 12.7% to 21.2%. The process is simpler and may be used in industry.

关 键 词：兰索拉唑 工艺改进 化学合成 质子泵抑制剂 

分 类 号：TQ463[化学工程—制药化工]