血液肿瘤患者化疗后院内血行感染细菌分布特点及药敏分析  

Analysis of the distribution characteristics and drug sensitivity of nosocomial infection in patient with hematologic neoplasms

作　　者：冷海燕[1] 柏岚[2] 陈字[1] 艾芙琪[2] 谢彦晖[1] 阮斐怡[2] 许小平[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040 [2]复旦大学附属华山医院检验中心,上海200040

出　　处：《白血病．淋巴瘤》2009年第2期90-92,共3页Journal of Leukemia & Lymphoma

摘　　要：目的了解血液肿瘤化疗患者院内血行感染细菌分布特点及药物敏感性。方法采用Kirby-Bauer法进行药敏试验，分析血液中分离得到的56株细菌。结果革兰阴性菌（G-）占69．64％，革兰阳性菌（G＋）占30．36％。以大肠埃希菌最为常见（37．50％），其次为肺炎克雷伯菌（10．71％）。葡萄球菌全部为耐甲氧西林葡萄球菌，仅对万古霉素敏感。结论血液肿瘤化疗患者院内血行感染仍以G-菌为主；大肠埃希菌最常见；葡萄球菌全部为耐甲氧西林葡萄球菌，仅对万古霉素100％敏感。Objective To investigate clinical distribution and drug sensitivity of infectious pathogens in our wards for hematology malignancies. Methods Drug sensitivity tests of bacteria were performed by Kirby-Bauer method, 56 strains of pathogens were isolated from all detected samples. Results The results showed that the composition ratio of Gram-negtive bacteria, Gram-positive bacteria was 69.64 %, 30.36 %. In decreasing frequency, Eseherichia coli （37.50 %）, Klebsiella pneumoniae （10.71%）. All of staphylococcies were resistant to meticillin, and sensitive to vancomycin. Conclusion This study indicates that Gramnegative bacteria remain the predominant pathogens in microorganisms causing bloodstream infections for hematological malignancies at Huashan Hospital. The incidence of Escherichia coli is the highest. All of staphyloeoecies were resistant to meticillin.

关 键 词：血液肿瘤 细菌感染 血液 耐药 

分 类 号：R446.5[医药卫生—诊断学]