nanos基因的研究进展  

Progress in nanos Gene

作　　者：张春冬[1] 潘敏慧[1] 李娜[1] 孙志亚[1] 谈娟[1] 鲁成[1] 

机构地区：[1]西南大学蚕学与系统生物学研究所,重庆400716

出　　处：《细胞生物学杂志》2009年第1期58-62,共5页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展规划(973计划)(No.2005CB121000);国家自然科学基金(No.30771630);重庆市自然科学基金计划(No.CSTC2007BB1337)资助项目~~

摘　　要：nanos基因在时空上的表达调控对于个体发育起着重要作用。母源nanos mRNA在卵子中的定位及翻译调控受到严格的控制。果蝇Nanos通过抑制后极hunchback mRNA的翻译建立胚胎后极信号中心,从而建立前后体轴;同时它对果蝇原始生殖细胞的决定及迁移有重要作用;Nanos对于胚后发育中生殖细胞的维持也是必须的。现对nanos基因的mRNA的定位、翻译调控及Nanos结构和功能的研究进展进行了综述。In many organisms, the regulations of the gene expression play important roles in the embryo- genesis and postembryogenesis, nanos mRNA encodes a regulatory factor of translation, so the location and trans- lation of maternal nanos mRNA in eggs are rigorous. In Drosophila melanogaster, maternal Nanos protein represses the translation of maternal hunchback mRNA in the posterior of the embryo to direct abdomen formation. The maternal Nanos protein is essential for the determination and migration of primordial germ cells and it is also required during the postembryogenesis. Here we review the nanos gene, including its localization of mRNA, control of translation, structure and function.

关 键 词：NANOS 原始生殖细胞 早期胚胎发育 

分 类 号：R346[医药卫生—基础医学]