儿童肺炎支原体感染检测MBL和CRP的意义  

The Role of Mannose-binding Lectin and C-reactive Protein Detection in Infected Children with Mycoplasma Pneumonia

作　　者：王艾丽[1] 严孝岭[1] 罗冰[1] 熊华[1] 

机构地区：[1]南京军区南京总医院临床中心实验科,江苏南京210002

出　　处：《标记免疫分析与临床》2009年第1期1-3,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨肺炎支原体(MP)感染患儿血清甘露糖结合凝集素(MBL)和C-反应蛋白(CRP)水平变化的意义。用ELISA和速率散射比浊法分别检测患儿血清MBL和CRP水平。结果显示,57例MP感染患儿MBL水平(3.64±1.72mg/L)和CRP(21.44±15.02mg/L)比对照组(2.18±1.05mg/L和2.76±1.81mg/L)显著增高(P<0.001)。年龄小于8岁患儿MBL水平低于年龄大于8岁患儿,其中8例反复呼吸道感染患儿MBL水平(2.02±1.21mg/L)显著低于其它患儿(3.95±1.63mg/L,P<0.01)。患儿恢复期CRP水平明显降低。结果提示,血清MBL和CRP水平可作为监测MP感染患儿天然免疫功能的指标,动态检测有助于评价疗效。To investigate mannose-binding lectin （MBL）and CRP levels in children with Mycoplasma pneumonia （MP）. The serum MBL and CRP levels were measured by nephelometry and ELISA. The results showed that MBL levels（3.64 ± 1.72mg/L） and CRP（21.44 ± 15.02mg/L） in 57 infected children with MP were significantly higher than that of control group （ P 〈 0. 001 ） . The MBL levels in children（≤8 years） were significantly lower than that in children（ 〉 8 years）. There was significant difference in MBL levels between 8 recurrent respiratory tract children and other infected children with MP（2.02 ± 1.21mg/L vs 3.95 ± 1.63mg/L,P 〈 0.01 ） . The CRP levels in infected children had declined in recovery phase . It suggested that the levels of MBL and CRP may be the monitoring indicator showing innate immune function in infected children with MP and it may be favourable to estimate curative effect by dynamicly detection.

关 键 词：肺炎支原体 甘露糖结合凝集素 C-反应蛋白 儿童 血清 

分 类 号：R725.6[医药卫生—儿科]