胍丁胺对先天嗜酒FH-Wjd大鼠饮酒行为的影响  

Effect of agmatine on alcohol-drinking behavior in alcohol-preferring FH/Wjd rats

作　　者：景丽[1] 邱毅[1] 张敏[1] 王卫平[1] CHEN Feng Andrew J LAWRENCE 李锦[4] 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083 [2]澳大利亚RMIT大学医学院,Victoria 3083 [3]澳大利亚Melbourne大学Howard Florey研究所,Victoria 3010 [4]北京毒物药物研究所,北京100850

出　　处：《中国新药杂志》2009年第3期243-247,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30570653,30870894);国家重大基础研究发展计划(973)项目(2003CB515400,2009CB522000)

摘　　要：目的:探讨胍丁胺对嗜酒FH/Wjd大鼠饮酒行为的影响。方法:利用FH/Wjd大鼠先天嗜酒的特点,采用双瓶(5%酒精和自来水)自由选择的方法,观察胍丁胺给药前后以及撤药后对FH/Wjd大鼠饮酒量、饮水量和酒精偏爱率的影响。结果:80和160 mg.kg-1胍丁胺皮下注射给药可明显抑制大鼠的饮酒量,与给药前(生理氯化钠溶液对照)相比,饮酒量分别下降25.9%和34.7%。进一步研究发现,500 mg.kg-1胍丁胺灌胃给药同样可以降低大鼠的饮酒量,与给药前(生理氯化钠溶液对照)相比,饮酒量下降41.2%。无论皮下注射或灌胃给药,大鼠的酒精偏爱率均呈现明显下降的趋势。给药期间饮水量呈现一定的上升趋势。灌胃给予胍丁胺对大鼠的进食量无明显影响。结论:胍丁胺能够降低嗜酒FH/Wjd大鼠的饮酒量,可能具有治疗酒精依赖的药理活性。Objective： To investigate the effect of agmatine on alcohol-drinking behavior in alcohol-preferring FH/Wjd rats. Methods： FH/Wjd rats were individually housed in standard plastic cages, and offered with two bottles, one filled with alcohol （5% in tap water, v/v） and the other with tap water. Alcohol, water and food consumption were monitored once daily during the period of pre- and post-treatment with saline or agmatine. Results： Compared with pre-treatment （saline control） , subcutaneous agmatine （80 and 160 mg·kg^-1） significantly reduced the daily alcohol consumption by 25.9% and 34.7% , respectively. Moreover, intragastric agmatine （500 mg·kg^-1 ） notably reduced alcohol consumption by 41.2%. In addition, a declining tendency of alcohol preference was observed in rats after subcutaneous and intragastric administration of agmatine. A slight increase was observed in water consumption during the period of treatment with agmatine. Intragastric administration of agmatine did not affect food consumption. Conclusion： Agmatine inhibits alcohol consumption in alcohol-preferring FH/Wjd rats, suggesting a potential to treat alcoholism.

关 键 词：胍丁胺 FH/Wjd大鼠 饮酒行为 

分 类 号：R163.2[医药卫生—公共卫生与预防医学] R965.1