甘精胰岛素联合阿卡波糖与预混胰岛素治疗2型糖尿病的效果比较  

Study on the effects of glargined with acarbose and isophane protamine biosynthetcic human insulin in patients with type 2 diabetic

作　　者：李艳萍[1] 李红梅[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750021

出　　处：《宁夏医学杂志》2009年第2期119-120,共2页Ningxia Medical Journal

摘　　要：目的比较甘精胰岛素(Glargine)联合阿卡波糖与预混胰岛素(精蛋白生物合成人胰岛素30R)治疗2型糖尿病的疗效及对血糖波动的影响。方法将65例2型糖尿病随机分为A组采用甘精胰岛素联合阿卡波糖治疗,B组采用预混胰岛素每日2次皮下注射。以空腹血糖(mFBG)<7mmol/L为目标,并监测早餐后2h血糖(mFP1G),午餐后2h血糖(mFP2G)和晚餐后2h血糖(mFP3G)计算1d4次血糖样本的标准差(SD),以及最高和最低血糖之差(Δ)。观察两组的血糖波动、胰岛素日用量、低血糖发生率。结果A组胰岛素日用量、低血糖发生率均低于B组(P<0.05),血糖波动小。结论甘精胰岛素联合阿卡波糖治疗2型糖尿病比预混胰岛素更利于血糖的平稳,低血糖的发生率低,波动影响更小,患者依从性好。Objective To compare fluctuation of blood glucose in type 2 diabetic patients treated by glargine combined with acarbose and isophane protamine biosynthetcic hunman insulin. Methods 65 patients with type 2 diabetic were randomly divided into two groups ： glargine groups （ n = 30） and pre - mixed insulin group （ n = 35 ） to compare Std. deviation, Range of blood glucose and insulin quantity , incidence of hypoglycemia. Results Glargine group was obviously lower than pre - mixed group in incidence of hypoglycemia and insulin quantity, Std. deviation, range of blood glucose. Coulusion Blood glucose is more stable in gargine group.

关 键 词：糖尿病 甘精胰岛素 预混胰岛素 血糖波动 

分 类 号：R587.1[医药卫生—内分泌]