三七总皂甙对急性脑梗死患者血浆同型半胱氨酸水平的影响  

The effect of panax notoginsenosides on the plasma homocysteine level of acute cerebral infarct patients

作　　者：董凌琳[1] 郭富强[1] 吴文斌[1] 汪瑾宇[1] 曾宪容[1] 

机构地区：[1]四川省人民医院神经内科,四川成都610072

出　　处：《四川医学》2009年第2期169-171,共3页Sichuan Medical Journal

摘　　要：目的观察三七总皂甙对急性脑梗死患者血浆同型半胱氨酸(HCY)水平的影响。方法选取符合标准的急性脑梗死患者60例,按数字随机法分为三七总皂甙加基础治疗(A)组(n=30)和基础治疗对照(B)组(n=30),治疗前和治疗两周后分别检测血浆HCY、维生素B12、叶酸(THF)水平,并与健康老年人对照。结果与健康组比较,脑梗死组血浆HCY水平显著升高、血清THF和维生素B12水平显著降低(P<0.01);A、B两组患者治疗后较治疗前血浆HCY水平显著降低、血清THF和维生素B12水平均显著升高(P<0.01);治疗后A组较B组血浆HCY水平显著降低、血清THF和维生素B12水平均升高明显(P<0.05)。结论三七总皂甙对血浆HCY水平有明显降低作用,其部分机制可能与三七总皂甙能显著升高血中THF和维生素B12水平有关。Objective To investigate effect of panax notoginsenosides on the plasma homocysteine level of acute cerebral infarct patients. Methods 60 patients were randomly divided into 2 groups-basic therapeutic group and panax notoginsenosides plus basic therapeutic group. The level of plasma HCY, Vit-B12, THF was tested before and after treatment, and comparing with the healthy subjects. Results The HCY level of patients with acute cerebral infarct was significantly elevated when compare to the healthy subjects, but the THF and Vit-B12 level were reduced. After the treatment,the HCY level of both groups was decreased significantly,and the plasma THF and Vit-B12 level were increased（ P 〈 0.01 ） .The HCY level of the group plus panax notoginsenosides was lower than the basic therapeutic group after treatment,and the level of THF and Vit-B12 in the group plus panax notoginsenosides was also higher than the basic therapeutic group（ P 〈 0.05）. Conclusion Panax notoginsenosides can lowering the plasma HCY level. The mechanism may involve the elevation of THF and Vit-B12 level.

关 键 词：三七总皂甙 急性脑梗死 血浆同型半胱氨酸 

分 类 号：R277.7[医药卫生—中医学]