TNHH对大鼠全脑缺血再灌注损伤的抗氧化性保护作用  

Antioxidant effects of TNHH on whole brain ischemia/reperfusion injury in rats

作　　者：于晓彦[1] 魏欣冰[1] 陈琳[1] 张岫美[1] 

机构地区：[1]山东大学医学院药理学研究所,山东济南250012

出　　处：《中国生化药物杂志》2009年第1期36-38,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察TNHH对大鼠全脑缺血再灌注损伤的抗氧化性保护作用。方法以改良的四血管阻塞法(Pulsinelli four-vessel occlusion model)建立大鼠全脑缺血模型,于缺血30 min,再灌注48 h后进行脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)、髓过氧化物酶(MPO)测定。结果TNHH能显著降低大鼠缺血损伤脑组织中MDA含量,降低MPO活性,提高SOD活性。结论TNHH对大鼠全脑缺血再灌注损伤的具有明显的抗氧化作用。Purpose To investigate the antioxidant effects of TNHH on global cerebral ischemia reperfusion injury in rats. Methods Modified Pulsinelli four-vessel occlusion model in rat was prepared to produce the cerebral ischemia reperfusion injury. After ischemia for 30 min and reperfusion for 48 h, superoxide dismutase （SOD）activity, malondialdehyde（MDA）level, and myeloperoxidase（MPO） activity in brain tissue were measured. Results TNHH produced significant reductions in MDA content, MPO activity and elevation in SOD activity. Conclusion TNHH possesses the antioxidant effects in whole brain ischemia reperfusion injury in rats.

关 键 词：脑缺血再灌注损伤 TNHH 抗氧化 

分 类 号：R965[医药卫生—药理学]