壳聚糖对巨噬细胞的双向免疫调节作用  

The bi-diretional immuno-modulatory effects of chitosan on macrophage

作　　者：王大山[1] 安利国[1] 杨桂文[1] 

机构地区：[1]山东师范大学生命科学学院,济南250014

出　　处：《生命的化学》2009年第1期60-63,共4页Chemistry of Life

基　　金：山东省自然科学基金重大项目(No.Z2003D01)资助

摘　　要：壳聚糖(chitosan)具有多种生物活性,如增强机体免疫力、激活免疫细胞等。近年来更多研究发现壳聚糖在炎症性疾病的治疗中起着重要作用,表明壳聚糖能弱化炎症处激活的免疫细胞,减轻免疫细胞浸润。本文将论述壳聚糖对一种重要的免疫细胞—巨噬细胞的双向免疫调节作用,以期为新型免疫调节药物的开发利用提供新的思路。Chitosan has many bioactivities, such as enhancing immune responses and activating immune cells. But in current researches, it has been found that chitosan also plays an important role in curing inflammation diseases, indicating that chitosan can also attenuate stimulated immune cells and inhibit infiltration. In this review, the bi-directional immuno-modulatory effects of chitosan on an important immune cell called macrophage were summarized. The in-depth research of chitosan will provide an important opportunity for the discovery and development of novel immuno-modulatory medicine.

关 键 词：壳聚糖 双向免疫调节 巨噬细胞 

分 类 号：R392[医药卫生—免疫学]