辐射诱导造血祖细胞(GM-CFU)的 HPRT 基因突变  

RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE

作　　者：杨凤桐[1] 孙元明[1] 崔惠爽 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所

出　　处：《辐射研究与辐射工艺学报》1998年第1期62-64,共3页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：研究了单次和分次１３７Ｃｓγ射线照射所致辐射残留损伤小鼠骨髓粒、巨噬系造血祖细胞（ＧＭＣＦＵ）的ＨＰＲＴ基因突变。结果证明单次照射时突变频率与照射剂量密切相关。总剂量相同的分次照射与单次照射的结果未见差异。辐射防护药ＷＲ２７２１对ＨＰＲＴ基因突变有防护作用。The HPRT gene mutation of haemopoietic progenitor cells (GM CFU) in mice suffered from residual injury induced by single dose and fractional dose 137 Cs γ ray irradiation were investigated. The results showed that the mutant frequency of GM CFU related closly to the radiation dose. No significant differences were found between single dose and fractional dose irradiation when total dose were 6.0Gy. The radioprotective agent, WR 2721, expressed a obvious protecitive function to HPRT gene mutation of bone marrow GM CFU in mice.

关 键 词：Γ辐射 HPRT基因突变 造血祖细胞 

分 类 号：Q345.2[生物学—遗传学]