益妇灵胶囊中挥发油β-环糊精包合工艺的研究  

Preparation of β-cyclodextrin in inclusion compound of volatile oil from yifuling capsule

作　　者：钱星文 雷晓林 张小红[2] 

机构地区：[1]东方药林药业有限公司,广东广州510515 [2]江西中医学院,江西南昌330004

出　　处：《安徽医药》2009年第2期141-142,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的考察益妇灵胶囊中莪术挥发油的包合方法,优选最佳的包合工艺。方法通过比较不同的包合方法,以莪术油的包合率为指标,确定包合方法和最佳包合工艺参数。结果胶体磨法较饱和水溶液法好,胶体磨法最佳的包合工艺为:油:β-环糊精=1∶8,研磨15 min,挥发油:95%乙醇=1∶1,莪术油的包合率为82%。结论所确定的工艺挥发油的包合率高,操作简单、时间短,耗能低,适合工业化大生产。Aim To study optimum inclusion process conditions for volatile oil from Yifuling capsule. Methods Based on the comparison of different ways, the application rate of included volatile oil was used as indexes to optimize way and the conditions for including the oils with β-CD. Results The method for colloid grinding was better than the saturating water solution one and the optimum preparation conditions for inclusion was established as follows ：volatile oil：β-CD was 1：8 ,inclusion time for 15 rain and volatile oil ：95% ETOH was 1： 1. Conclusion The optimum process is fit for mass production, with advantages of high inclusion rate,simple operation, short time and low energy consumption.

关 键 词：莪术油 正交试验 包合物 包合率 

分 类 号：TQ461[化学工程—制药化工]