养肝益水颗粒对SHR大鼠血压及ET-1、NO的影响  

Effect of yangganyishui granule on blood pressure,ET-1 and NO in SHR

作　　者：戴小华[1] 郑林 杨帆[1] 梁国庆[1] 

机构地区：[1]安徽中医学院第一附属医院心内科,安徽合肥230031 [2]浙江省象山县第一人民医院,浙江象山315700

出　　处：《安徽医药》2009年第2期147-149,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的通过对自发性高血压大鼠(SHR)血压、循环及肾脏组织内皮素(ET-1)、一氧化氮(NO)浓度的检测,观察养肝益水颗粒对SHR大鼠肾脏保护作用。方法将SHR大鼠随机分为养肝益水颗粒治疗组(以下简称养肝益水组)、卡托普利治疗组(以下简称卡托普利组)、模型对照组,每组均8只,Wistar-Kyoto(WKY)大鼠8只作为正常对照组。灌胃6周后处死,检测其血压、循环及肾脏组织内ET-1及NO的浓度。结果养肝益水颗粒能降低SHR大鼠血压进行性增高的趋势;治疗后养肝益水组循环ET-1浓度略有下降,但与模型对照组比较无明显差异(P>0.05);治疗后养肝益水组肾脏组织ET-1浓度较模型对照组有显著下降,其差异有统计学意义(P<0.01);治疗后养肝益水组循环NO浓度略有升高,但与模型对照组比较无明显差异(P>0.05),与正常对照组比较其差异有统计学意义(P<0.05);治疗后养肝益水组肾脏组织NO浓度较模型对照组有显著升高,其差异有统计学意义(P<0.01)。结论养肝益水颗粒能持久降低SHR大鼠血压,降低SHR大鼠肾脏组织ET-1浓度;升高SHR大鼠肾脏组织NO浓度,从而起到保护肾脏的作用。Aim To observe the protective effect of yangganyishui granule on spontaneous hypertension rats （SHR） with early renal damage by detecting the blood pressure, endothelin-1 （ ET-1 ） concentrations and nitricoxide （NO） concentrations of SHR. Methods Twenty-four SHR were randomly divided into three groups which include yangganyishui granule group, captopril group, model control group. Each group has eight rats. Besides, eight Wistar-Kyoto（WKY） rats belong to normal control group. After 6 weeks, all of the rats were put to death. Their blood pressure,ET-1 concentrations and NO concentrations were measured. Results yangganyishui granule group could reduce their increasing blood pressure. The comparison of the circulating ET-1 concentrations between yangganyishui granule group and model control group was not statistically significant （ P 〉 0.05 ） after treatment. The nephric ET-1 concentrations of the yangganyishui granule group has some statistical significance （P 〈0.01 ） compared with the model control group after treatment. There was no statisticall significance （ P 〉 0.05 ） in circulating NO concentrations of the yangganyishui granule group were compared with the model control group after treatment. BUt, there is statistical significance （ P 〈 0.05 ） compared with the normal control group. It was statistically significant （P 〈 0.01 ） when the nephric NO concentrations of the yangganyishui granule group was compared with the model control group after treatment. Conclusions Firstly, yangganyishui granule could persistently decrease the SHR＇ s blood pressure. Secondly,it could not only decrease the nephric ET-1 concentrations but increase the nephric NO concentrations. Therefore,it has some protective effects on spontaneous hypertension rats（SHR） with early renal damage.

关 键 词：养肝益水颗粒 自发性高血压大鼠 早期.肾损害 血压 ET-1 NO 

分 类 号：R285[医药卫生—中药学]