2-[1-(1,2,4-三唑)甲基]-3-乙酰基-2,5-二取代芳基-1,3,4-噁二唑啉类化合物的合成  

Synthesis of 3-Acetyl-2,5-di[(un)substituted phenyl]-2-(1,2,4-triazol-1-ylmethyl)-1,3,4-oxadiazoline

作　　者：杨德保[1] 刘方明[1] 杨春[1] 沈松伟[1] 周英雷[1] 徐峰[1] 叶嘉炜[1] 

机构地区：[1]杭州师范大学材料与化学化工学院,杭州310036

出　　处：《有机化学》2009年第2期269-273,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.29702007;20162004)资助项目

摘　　要：在冰醋酸存在下,4-取代苯乙酮和溴素容易进行溴代反应,得到α-溴-4-取代苯乙酮;将其和1,2,4-三唑在丙酮中反应,得到α-(1,2,4-三唑-1-基)-4-取代苯乙酮2;在冰醋酸催化下,2和4-取代苯甲酰肼1进行缩合,得到相应酰腙衍生物3;化合物3在乙酸酐的作用下环化生成一系列2-[1-(1,2,4-三唑)甲基]-3-乙酰基-2,5-二取代芳基-1,3,4-噁二唑啉4.化合物4的结构经IR,1HNMR,MS,元素分析和单晶衍射确证.In the presence of glacial acetic acid, 4-substituted acetophenone was brommated easily to afford α-bromo-4-substituted acetophenone, which was reacted with 1,2,4-triazole in acetone to get α-（1,2,4-triazole-1-yl）-4-substituted acetophenone （2）. Reaction of 4-substituted benzohydrazide （1） with compound 2 gave the corresponding hydrazones 3, which could be readily converted to their congener oxadiazolines 4 in good yields by treatment with acetic anhydride. Compounds 4 were confirmed by IR, ^1H NMR, MS, elemental analysis and single crystal X-ray diffraction.

关 键 词：1H-1 2 4-三唑 1 3 4-噁二唑 合成 晶体结构 

分 类 号：TQ463.53[化学工程—制药化工]