等渗与低渗盐水防治造影剂肾病的效果比较  

Comparative study on the effect of isotonic and hypotonic sodium chloride solution in prevention of CIN in patients undergoing cardio angioplasty

作　　者：吴英凤[1] 徐立滨[1] 

机构地区：[1]天津大港油田总医院,天津300280

出　　处：《海南医学》2009年第3期16-18,共3页Hainan Medical Journal

摘　　要：目的比较等渗(0.9%氯化钠水溶液)与低渗(0.45%氯化钠水溶液)盐水对心脏介入术所导致的造影剂肾病(CIN)的防治效果。方法将184例接受心脏介入术的患者随机分为A、B两组,于术前12h至术后12h分别静脉滴注低渗与等渗盐水,观察两组造影剂肾病的发病例数、术前1d、术后24、48h及第7d血清肌酐(SCr)、肌酐清除率(CCr)的变化,记录造影剂的用量。结果B组(等渗)较A组(低渗)CIN的发生例数明显减少,无合并症的患者无一例发生CIN,有单一合并症者两组间CIN发生率无统计学差异。结论为防治心脏介入诊疗术中造影剂肾病(CIN)的发生,在围手术期应用等渗盐水较低渗盐水效果更好。Objective To evaluate the efficacy of 2 types of hydration regimens in the patients undergoing cardioangioplasty in the prevention of contrast medium induced nephropathy（CIN）. Methods 184 patients undergoing cardio angioplasty were randomly divided into 2 groups ： A and B. The patients in group A were treated with intravenous drip of 0. 45% NaCl solution and group B with 0. 9% NaCl solution during 12 hours before and after operation. The dose of contrast medium was recorded. The level of serum creatinine （ SCr）, ereatinine clearance （CCr） 1 day before and 24, 48 hours, 7 days after coronary angioplasty and the number of patients developing CIN in both groups were observed. Results The number of CIN cases in goup B was much less than that in group A（ P 〈 0. 05 ）. There was no cases of CIN in the patients without risk factors（ renal dysfunction, hypertention, diabetes, heart failure, et al）. There was no statistic difference between the two groups in the patients with risk factors. Conclusion To prevent CIN, the transfusion of 0. 9% NaCl solution is better than 0. 45% NaCl solution in the patients undergoing cardio angiopasty in perioprative period

关 键 词：造影剂肾病 等渗盐水 低渗盐水 心脏 

分 类 号：R692[医药卫生—泌尿科学]