牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响(英文)  

Study on the Effects of Learning and Memory Ability for Rats and Mice Exposed to Chronic Mercury

作　　者：赵文涛[1] 张顺三[2] 高洁[1] 李积胜[3] 

机构地区：[1]沧州医学高等专科学校解剖教研室,河北沧州061001 [2]河北省沧州市疾病预防控制中心,河北沧州061001 [3]武警医学院军事预防医学研究所,天津300162

出　　处：《河北北方学院学报（医学版）》2009年第1期5-7,共3页Journal of Hebei North University:Medical Edition

基　　金：天津市自然科学基金重点资助项目(编号:003804411)

摘　　要：目的:探讨牛磺酸锌(TZC)拮抗汞对神经系统的损害作用。方法:选用健康Wistar大鼠64只,昆明种小鼠60只分别随机分组,对照组、染汞组、汞+TZC组,大鼠采用Y迷宫,小鼠采用穿梭实验,观察染汞组和不同浓度TZC组的鼠学习记忆能力的变化。结果:汞可导致大鼠学习记忆能力下降(P<0.05),不同浓度的TZC均可缓解汞致大鼠学习记忆能力下降(P<0.05)。结论:TZC在一定程度上能拮抗汞对神经系统毒性作用。Objective.. To study the different dosages of taurine-zinc coordination compound（TZC）on resisting the impairment of mercury（Hg） induced CNS damage. Methods： The chosen rats and mice were divided into control group, Hg group, Hg＋TZC group. The effected differences for learning memory ability were observed with the Y maze test and shuttle before and after experiment. Results： Mercury can lead to decrease of leaning and memory ability（P〈 0. 05）, each zinc-supplement group can mitigate the damage induced by mercury in different degree（P〈0.05）. Conclusions .. The resistance effect of TZC on the toxic of Hg is related to the form of zinc-compound and the dosage of TZC.

关 键 词：牛磺酸锌 汞 学习 记忆 

分 类 号：R965[医药卫生—药理学]