脑损伤患者听觉P300电位特点  

Auditory P300 in the Patients with Traumatic Brain Injury

作　　者：崔勇[1,2] 刘帆[3] 张馨元[1] 汤鹏[1] 刘鹏[1] 张彪[1] 刘技辉[1] 

机构地区：[1]中国医科大学法医学院临床法医学教研室,辽宁沈阳110001 [2]辽宁中医药大学基础医学院,辽宁沈阳110032 [3]中国医科大学,93期口腔医学专业辽宁沈阳110001

出　　处：《法医学杂志》2009年第1期19-23,共5页Journal of Forensic Medicine

基　　金：沈阳市科学技术计划项目(1081267-9-00)

摘　　要：目的探讨听觉P300电位对脑损伤患者认知功能障碍程度法医学评价的应用价值。方法对正常人和脑损伤患者,分别在主动(踩踏板)与被动任务状态下进行听觉P300测试。结果正常人主动任务状态P300电位中的N2、P3波波幅较被动状态高,潜伏期无明显延长,N1、P2波幅Cz点高于Pz点。脑损伤组被动任务状态下N2、P3波波幅较正常人被动状态下高,且潜伏期延长。脑损伤组主动任务状态P300电位中的N2、P3波波幅较被动状态高,且潜伏期延长。注意障碍患者P3波潜伏期改变最明显。结论任务类型主要影响N2、P3波幅。被动反应中的N2、P3潜伏期可作为评价脑损伤患者认知功能的指标。Objective To assess the cognitive dysfunction in patients with the traumatic brain injury（TBI） by auditory P300. Methods Auditory P300 was recorded in the normal subjects and patients with TBI at the active（foot pedal） and passive task. Results In healthy persons, N2 and P3 in active task state showed higher amplitude than that in passive task state, and no significant prolongation of the latency. The amplitude of N1 and P2 at Cz was higher than that at Pz. In passive task state, N2 and P3 showed higher amplitude and longer latency in the patients than that in the heahhy persons. N2 and P3 of the patients in the active task showed higher amplitude and longer latency than that in the passive task. Obvious change of P3 latency was observed in the patients with attention disorder. Conclusion The type of task mainly affect the amplitude of N2 and P3. The latency of N2 and P3 in passive task can be used as an indication for evaluating cognitive function in patients with diffuse brain injury.

关 键 词：法医学 事件相关电位 P300 脑损伤 认知 

分 类 号：DF795.1[医药卫生—法医学]