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作 者:吴冬冬[1] 伟忠民[1] 逄秀娟[2] 余克富[2]
机构地区:[1]辽宁医学院附属第一医院,辽宁锦州121000 [2]沈阳药科大学药学院,辽宁沈阳110016
出 处:《辽宁医学院学报》2009年第1期65-68,共4页Journal of Liaoning Medical University (LNMU) Bimonthly
摘 要:目的制备布洛芬固体脂质纳米粒(solid lipid nanoparticles,SLN)并优化其处方。方法采用乳化分散-超声法制备布洛芬SLN,以包封率为评价指标,进行正交实验筛选最优处方。结果通过正交筛选,得到的最优处方为布洛芬0.05 g、F-68 0.35 g、正丁醇2 mL、卵磷脂0.15 g、单硬脂酸甘油脂0.05 g。结论用该工艺和处方制备的布洛芬SLN符合制剂学性质要求。Objective To prepare solid lipid nanoparticles (SLN) loaded with ibuprofen and improve its prescription. Methods Ibuprofen - SLN was prepared by emulsification dispersion - ultrasonieation method. Orthogonal experiment design was conducted to se- lect the optimal formulation, which was based on the encapsulate efficiency ( EE% ) . Results Based on the Orthogonal experiment, the optimal formulation were Ibuprofen 0.05 g, Pluronie F - 68 0. 35 g , 1 - butanol 2 mL, lecithin 0. 15 g, glyeeryl monostearate 0. 05 g. Conclusions The results suggested that Ibuprofen - SLN prepared by this prescription and technology was consistent with the demand of nano - preparations.
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