布洛芬固体脂质纳米粒的制备  

Preparation of Solid Lipid Nanoparticles Loaded with Ibuprofen

作　　者：吴冬冬[1] 伟忠民[1] 逄秀娟[2] 余克富[2] 

机构地区：[1]辽宁医学院附属第一医院,辽宁锦州121000 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《辽宁医学院学报》2009年第1期65-68,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的制备布洛芬固体脂质纳米粒(solid lipid nanoparticles,SLN)并优化其处方。方法采用乳化分散-超声法制备布洛芬SLN,以包封率为评价指标,进行正交实验筛选最优处方。结果通过正交筛选,得到的最优处方为布洛芬0.05 g、F-68 0.35 g、正丁醇2 mL、卵磷脂0.15 g、单硬脂酸甘油脂0.05 g。结论用该工艺和处方制备的布洛芬SLN符合制剂学性质要求。Objective To prepare solid lipid nanoparticles （SLN） loaded with ibuprofen and improve its prescription. Methods Ibuprofen - SLN was prepared by emulsification dispersion - ultrasonieation method. Orthogonal experiment design was conducted to se- lect the optimal formulation, which was based on the encapsulate efficiency （ EE% ） . Results Based on the Orthogonal experiment, the optimal formulation were Ibuprofen 0.05 g, Pluronie F - 68 0. 35 g , 1 - butanol 2 mL, lecithin 0. 15 g, glyeeryl monostearate 0. 05 g. Conclusions The results suggested that Ibuprofen - SLN prepared by this prescription and technology was consistent with the demand of nano - preparations.

关 键 词：布洛芬 固体脂质纳米粒 制备 处方筛选 

分 类 号：R94[医药卫生—药剂学]