急性CCl4肝损伤对大鼠芍药苷药代动力学的影响  

Pharmacokinetics of paeoniflorin in acute liver injury rats induced by CCl_4

作　　者：李娜[1,2] 吴磊[1] 苏云明[2] 陈西敬[1] 

机构地区：[1]中国药科大学药物代谢动力学重点实验室,南京210009 [2]黑龙江中医药大学,哈尔滨150040

出　　处：《中国药科大学学报》2009年第1期77-79,共3页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30472060);国家高技术研究发展计划(“八六三”计划)资助项目(No.2007AA02Z171)~~

摘　　要：目的:研究芍药苷在CCl4所致急性肝损伤大鼠中的药代动力学。方法:反相HPLC法(内标为栀子苷)测定大鼠血浆中的芍药苷浓度。用CCl4制造大鼠急性肝损伤模型。动物分对照组和实验组,给药途径为尾静脉注射,剂量为3 mg/kg。结果:在大鼠急性CCl4肝损伤模型中,芍药苷的多个药代动力学参数(除了MRT)与对照组相比,均有显著性差异。结论:肝损伤会明显改变芍药苷在大鼠体内的药动学行为,可为临床芍药苷的应用提供参考。Aim： To study the pharmacokinetics of paeoniflorin in acute liver injury rats induced by CCl4. Methods： A simple, sensitive and rapid HPLC method （jasminoidin as internal standard） was used to determine the level of paeoniflorin in rat plasma. In the experimental group, the acute liver injury model was made by CCl4 rats were divided into control and experimental groups. Then paeoniflorin was given via caudal vein at a dose of 3 mg/kg in both groups. Results： Compared with those of the control group, most of the pharmacokinetic parameters of the experimental group had significant changes. Conclusion： The status of acute liver injury induced by carbon tetrachloride could change the pharmacokinetics of paeoniflorin in rats. This result obtained from the present study could provide reference for evaluating its relevant clinical efficacy.

关 键 词：芍药苷 急性肝损伤 药代动力学 高效液相色谱法 

分 类 号：R285[医药卫生—中药学]