CD4+CD25+Foxp3Treg细胞在再生障碍性贫血诊断中的应用  

Application of CD4+CD25+Foxp3Treg Cells in the Diagnosis of Aplastic Anemia

作　　者：黄芳媚[1] 赖永榕[1] 

机构地区：[1]广西医科大学第一附属医院血液内科

出　　处：《医学综述》2009年第5期665-669,共5页Medical Recapitulate

摘　　要：CD4^＋CD25^＋Foxp3Treg调节性T细胞（Treg）具有维持自身免疫耐受和调节免疫应答的功能，其功能紊乱或数目下降是导致自身免疫性疾病的重要原因之一。许多研究证实，Foxp3在调控CD4^＋CD25^＋Foxp3Treg细胞的发育和功能上起着重要作用。近年来发现，CD4^＋CD25^＋Foxp3Treg在再生障碍性贫血疾病的发病过程中，存在着数量和功能的异常，是否能将CD4^＋CD25^＋Foxp3Treg在再生障碍性贫血中数量和功能的异常作为再生障碍性贫血与其他临床症状与再生障碍性贫血相似，目前实验手段难以鉴别的疾病区分开来，本文就对此作一综述。The function of regulatory T cell is to maintain autoimmune tolerance and regulate immune response. Functional disorder of regulatory T cell is the importion reason leading to the autoimmune disease. Foxp3 gene plays a significance role in cells development and function which have been confirmed by many investigations. Recent years, CD4^＋ CD25^＋ Foxp3 regulatory T cells have dysfunction in its quantity and function during the genesis of aplastic anemia. It is suspending whether the Treg cell can be used to identify aplastic anemia among these diseases having the similar clinical manifestation that can not be differentiated by experimental method at present. So, this article reviews the progresses related to it.

关 键 词：CD4+CD25+TREG细胞 FOXP3 再生障碍性贫血诊断 

分 类 号：R556.5[医药卫生—血液循环系统疾病]