抑郁症首次发病患者海马磁共振质子波谱成像的研究  

A proton magnetic resonance spectroscopy imaging study in hippocampus in patients with primary depression

作　　者：郑华[1] 王默力[2] 段冬梅[3] 于春水[4] 图娅[5] 

机构地区：[1]北京丰台医院神经内科,100071 [2]首都医科大学宣武医院神经内科 [3]解放军总医院针灸科 [4]首都医科大学宣武医院放射科 [5]北京中医药大学针灸系

出　　处：《神经疾病与精神卫生》2008年第6期414-416,共3页Journal of Neuroscience and Mental Health

基　　金：北京市自然科学基金项目(7051003)

摘　　要：目的探讨抑郁症首次发病患者海马的磁共振质子波谱(1H-MRS)代谢物质的变化。方法对99例首次发病的抑郁症患者和26例健康对照组行磁共振常规扫描及1H-MRS检查,测量双侧海马N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)和肌酸(Cr)三种代谢物质,计算NAA/Cr和Cho/Cr比值。结果抑郁症患者海马NAA/Cr左右侧比值(1.23±0.16;1.16±0.16)低于对照组NAA/Cr左右侧比值(1.38±0.23;1.31±0.26),差异有显著性(P<0.05);抑郁症患者海马体部Cho/Cr左右侧比值(1.19±0.14;1.18±0.12)高于对照组Cho/Cr左右侧比值(1.14±0.12;1.11±0.14),差异有显著性(P<0.05)。对照组左右侧NAA/Cr和Cho/Cr比较差异无显著性(P>0.05)。抑郁症组右侧NAA/Cr低于左侧,差异显著(P<0.05);左侧Cho/Cr高于右侧,差异不明显(P>0.05)。结论抑郁症患者可能存在双侧海马神经细胞代谢功能障碍,右侧神经细胞功能障碍较左侧明显。Objective To evaluate the possible alteration of brain metabolism function in hippocampus in patients with primary depression using proton magnetic resonance spectroscopy （^1H-MRS）. Methods ^1H-MRS were obtained in hippocampus from 99 patients with primary depression and 26 healthy human as a control group, by using a conventional magnetic resonance scanning. Further, the three metabolistic substances, N-acetyl aspartate （NAA）, Choline （Cho）, and Creatine （Cr） in hippocampus in both sides were measured; and the ratio of NAA/Cr and Cho/Cr were calculated. Results The NAA/Cr ratio in left and right hippocampus in patients with primary depression （1.23±0. 16 ; 1. 16 ± 0.16） were lower than those in healthy controls （1.38±0.23;1.31 ± 0.26）, with a significent difference （P 〈 0.05）. The Cho/Cr ratio in left and right hippocampus in patients with primary depression （1.19 ±0.14;1.18±0.12） were higher than those in healthy controls （1.14±0.12;1. 11±0.14）, showing a significent difference （P 〈 0.05）. There were no significant differences between left NAA/Cr Cho/Cr and right NAA/Cr Cho/Cr in normal controls （P 〉0.05）. The right NAA/Cr ratio was lower than that of the left in patients with primary depression （P〈0.05）. However, there was obviously differences between left Cho/Cr and right Cho/Cr （P 〉 0.05）. Conclusions There rnight exist abnormal metabolism function of neuron cell in bilateral hippocampal nerve cells. The right hippocampal dysfunction is more obviously than that of the left.

关 键 词：抑郁症 海马 磁共振波谱学 

分 类 号：R749.41[医药卫生—神经病学与精神病学]