紫杉醇微乳抗肿瘤作用的研究  

Anticancer effect of paclitaxel carried with coix seed oil microemulsions

作　　者：王俊平[1] 王玮[1] 赵丽妮[1] 

机构地区：[1]辽宁省沈阳医学院药理学教研室,110034

出　　处：《中国现代医药杂志》2009年第2期10-12,共3页Modern Medicine Journal of China

基　　金：辽宁省教育厅资助项目(项目编号:2004F068)

摘　　要：目的采用薏米仁油研制紫杉醇微乳,评价其抗肿瘤作用。方法采用聚乙二醇-二硬脂酰基磷脂酰乙醇胺(PEG-DSPE)和薏米仁油,制备紫杉醇微乳,并测定其Zeta电位和粒度分布。评价紫杉醇微乳对小鼠的急性毒性及其抗肿瘤作用。结果紫杉醇微乳粒径为112.6±2.5nm,Zeta电位为-32.4±3.5mV。在本实验条件下,紫杉醇微乳显著降低了紫杉醇的急性毒性,紫杉醇和薏米仁油具有显著的协同抗肿瘤作用(P<0.01)。结论我们制备的紫杉醇微乳有可能成为一种较好的抗肿瘤药物。Objective To prepare coix seed oil microemulsion to carry paclitaxel and evaluate its acute toxicity and anticaneer effect. Methods The paclitaxel microemulsion was a semi-transparent solution containing paclitaxel, coxi seed oil and PEG-DSPE （polylene glycol derivative of distearoyl phosphatidyl ethanolamine, mean molecular weight of PEG： 2000）. The Zeta potential and particle size distribution were determined using a laser light scattering instrument. The acute toxicity of the pacli- taxel microemulsion was studied using mice and its anticancer effect was evaluated using Lewis lung and M5076 tumor models. Results The average diameter of the paclitaxel microemulsion was 112.6±2.5nm and its Zeta potential was -32.4±3.5mV while its paclitaxel concentration was 0.29mg/mL. Compared with paclitaxe and coxi seed oill, the paclitaxel microemulsions showed lower acute toxicity and synergysitic anticancer effect. Conclusion The paclitaxel microemulsion may become a better anti- cancer drug than paclitaxel and coxi seed oil.

关 键 词：紫杉醇微乳 薏米仁油 急性毒性 协同抗肿瘤作用 

分 类 号：R285[医药卫生—中药学]