强心益气汤对慢性压力超负荷大鼠心室重构的影响  

Effects of Qiangxinyiqi decoction on myocardium remodeled rats with chronic pressure overload

作　　者：胡玉录[1] 张建平[2] 吴明华[2] 张伟[2] 徐华洲[2] 李乾[2] 楚立[2] 

机构地区：[1]河北医科大学第二医院药剂科,石家庄050000 [2]河北医科大学基础课教学部,石家庄050091

出　　处：《中华中医药杂志》2009年第3期281-283,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省科技厅科技攻关课题(No.06276102D-29);河北省中医药管理局课题(No.2007023)

摘　　要：目的:探讨强心益气汤对慢性压力超负荷大鼠心室重构的影响。方法:将48只SD大鼠随机分成4组,进行肾上腹主动脉部分结扎。假手术组和手术组不予治疗,治疗组于术后分别给予不同剂量强心益气汤灌胃,第4周分别测定各组左室质量指数(LVMI)、心肌胶原容积分数(CVF)和血浆AngⅡ、ALD含量。结果:与假手术组相比,手术组大鼠血浆AngⅡ、ALD含量升高,LVMI、CVF均升高,可见大量胶原沉积,具有非常显著性差异(P<0.01);与手术组相比,各治疗组可见AngⅡ、ALD含量降低,LVMI、CVF均降低,胶原沉积较少,具有显著性差异(P<0.05,P<0.01)。结论:强心益气汤可对抗腹主动脉结扎所致压力超负荷大鼠心脏重构,减少胶原沉积,阻止和延缓慢性心功能不全的发生发展,部分机制可能与减少机体AngⅡ及ALD含量有关。Objective： To observe the effects of Qiangxinyiqi decoction （QXYQD） on myocardium remodeled rats with chronic pressure overload. Methods： Pressure overload rat models were established by partly constricting the abdominal aortas. 48 adult male SD rats were randomly divided into 4 groups： operation group （OG）, sham operation group （SOG）, low-dose QXYQD group, high-dose QXYQD group. L-QXYQD group and H-QXYQD group were orally administered with Qiangxinyiqi decoction after operation. The other 2 groups were given the same amount of saline in the same way. The contents of Ang Ⅱ and ALD in plasma, left ventricular weights of the four groups were recorded, and collagen volume fraction （CVF） was determined by videodensitometry at 4th week after operation. Results： Compared with OG group, the Ang Ⅱ and ALD of the SOG group significantly increased（P〈0.01）;compared with SOG group, those of each treatment group decreased, which had a significant difference（P〈0.05,P〈0.01）; compared with OG group, a lot of collagen accompanied of the myofibrilla in the SOG group, the LVMI and CVP of MC group were higher, which had a significant difference （P〈0.01）; compared with OG group, those of each treatment group were lower ,which had a significant difference（P〈.0.05,P〈0.01）. Conclusions： Qiangxinyiqi decoction has beneficial effects on myocardium remodeling, can lighten and postpone the accumulation of myocardial collagen of rats with pressure overload, which may partly depend on decreasing the contents of Ang Ⅱ and ALD in plasma.

关 键 词：心功能不全 压力超负荷 心肌重构 强心益气汤 

分 类 号：R285.5[医药卫生—中药学] R542.22[医药卫生—中医学]