扶正排毒片Ⅱ号治疗无症状HIV感染者65例疗效观察  

Clinical observation on 65 cases of HIV asymptomatic carriers treated by FuzhengPaidu Tablet Ⅱ

作　　者：王丹妮[1,2] 郭会军[1,3,4] 李华伟[3,4] 蒋自强[1] 刘学伟[3,4] 姜枫[1] 彭勃[3,4] 

机构地区：[1]河南中医学院第一附属医院艾滋病临床研究中心,郑州450000 [2]南京中医药大学,南京210046 [3]河南省病毒性疾病中医药防治重点实验室,郑州450008 [4]河南中医学院艾滋病研究所,郑州450008

出　　处：《中华中医药杂志》2009年第3期385-388,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家“973”重点课题资助项目(No.2006CB504802);河南省创新人才基金资助项目(No.0521002500);河南省教育厅科技攻关项目(No.2007360023)

摘　　要：目的:观察扶正排毒片Ⅱ号对无症状HIV感染者的临床疗效,为扶正排毒片Ⅱ号的临床应用提供客观有力的临床证据,并为针对无症状HIV感染者中药新药的研制奠定基础。方法:选择符合纳入标准的无症状HIV感染者65例,服用扶正排毒片Ⅱ号治疗,每次5片,每天3次,3个月为1疗程,观察4个疗程。观察感染者治疗前后临床症状、体征及CD4+细胞的变化。结果:症状、体征总有效率为92.31%。扶正排毒片Ⅱ号对CD4+计数为200/mm3-350/mm3区间的感染者有效率为50.0%,351/mm3-450/mm3区间的感染者有效率为66.6%,451/mm3以上的感染者有效率为72.8%。结论:扶正排毒片Ⅱ号治疗无症状HIV感染者疗效肯定,可明显改善临床症状、体征,提高免疫功能,并且对CD4细胞在451/mm3-600/mm3之间的无症状HIV感染者疗效更好。Objective ：To observe the clinical effect of FuzhengPaidu Tablet Ⅱ on HIV asymptomatic carders, offer objective and forcible clinical evidence for the clinical application, and establish foundation of manufacturing Chinese traditional medicine new drug for HIV asymptomatic carriers. Methods： 65 cases of HIV asymptomatic carders were adopted. Each case was treated with FuzhengPaidu Tablet Ⅱ ,5 tablets t.i.d., three months as a period of treatment and four periods of treatment were observed. Changes of symptom, immune function and security index were checked-up before and after treatment. Results： The total effective rate of symptoms and physical sign was 92.31%. Different levels of CD4^＋ had different changes. Effective rate of FuzhengPaidu Tablet Ⅱ on CD4^＋ was superior in 451-600/mm^3 （72.8%）to that in 200-350/mm^3（50%） or 351-450/mm^3（66.6%）. Conclusion： FuzhengPaidu Tablet Ⅱ could obviously improve symptoms and physical sign of HIV asymptomatic carriers. The results indicated that it can raise or stabilize immune function, had better effect in treating cases with CD4^＋ in 451-600/mm^3.

关 键 词：扶正排毒片Ⅱ号 无症状HIV感染者 中医药疗法 

分 类 号：R259[医药卫生—中西医结合]