黛矾散治疗肝内胆汁淤积症的临床研究  

Curative effect of Daifan powder on intrahepatic cholestasis

作　　者：程良斌[1] 余晓丽[2] 

机构地区：[1]湖北省中医院感染科,湖北武汉430061 [2]武汉市医疗救治中心

出　　处：《中西医结合肝病杂志》2009年第1期10-12,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：湖北省教育厅科研课题(No.2001A04008)

摘　　要：目的:观察黛矾散治疗肝内胆汁淤积症的临床疗效及安全性。方法:70例肝内胆汁淤积患者按就诊顺序随机分为两组,各35例。治疗组患者以基础治疗加黛矾散(1.5g次/,3次/d)口服;对照组患者以基础治疗加熊去氧胆酸(150mg/次,3次/d)口服。分别检测其血清总胆红素(TB il)、直接胆红素(DB il)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)、总胆汁酸(TBA)、γ-谷氨酰转肽酶(GGT),观察各项临床症状变化。结果:治疗组临床治愈率28.57%,总有效率88.57%;对照组分别为14.29%、54.29%。治疗组疗效优于对照组,两组间比较差异有显著性意义(P<0.05)。治疗组临床症状和体征改善情况优于对照组(P<0.05)。治疗后TB i、lDB i、lALT、TBA、ALP、GGT水平治疗组与对照组比较差异有显著性意义(P<0.05)。两组均未发现明显毒副作用。结论:黛矾散治疗肝内胆汁淤积症具有良好的临床疗效及安全性。Objective： To observe the clinical curative effect and safety of Daifan powder on the peatients with intrabepatic cholestasis. Methods： Seventy patients were randomly divided into the treatment group （35 cases） with Daifan powder （1.5g, tid, po） and the control group （35 cases） with the Ursodeoxycholic Acid tablets （150mg, tid, po） . Both groups took the medicine continuously for 30 days. After the treatment for 15 days, and in the end of the treatment, compared the level of TBil, DBil, ALT, ALP, GGT and clinical symptoms and physical sign changes of the two groups and also compared their symptom scores. Results： The healing efficacy of the treatment group was better than that of the control group, and had significant difference （P 〈0. 05） . The TBil, DBil, ALT, TBA, ALP levels of the treatment group were lower than that before the treatment, and there were significant differences （ P 〈 0.05 ） . Conclusion： Daifan powder can improve the clinical symptoms, physical signs of the intrahepatic choles tasis patients and significantly improve the quality of their life, and can effectively reduce the levels of serum TBil, DBil, ALT, TBA, ALP.

关 键 词：黛矾散/治疗应用 肝炎 病毒性 人 肝内胆汁淤积症 

分 类 号：R259[医药卫生—中西医结合]