Hcy与TpP用于ACI早期诊断的价值  

Clinical Value of Serum Hcy and Thrombo-precursor Protein (TpP) Levels Determination of Early Diagnosis of Acute Cerebral Infarction

作　　者：谭滢[1] 张吉才[1] 胡秀学[1] 

机构地区：[1]湖北省十堰市郧阳医学院附属太和医院检验部,442000

出　　处：《放射免疫学杂志》2009年第1期67-68,共2页Journal of Radioimmanology

摘　　要：目的:探讨同型半胱氨酸(Hcy)及血栓前体蛋白(TpP)检测在急性脑梗死(ACI)早期诊断中的价值。方法:用ELISA对64例ACI患者,在发病后48h及以内不同时期的血浆Hcy、TpP及D-二聚体(D-D)含量进行检测,并与正常组比较。结果:ACI患者在治疗前血浆TpP、Hcy含量显著高于正常对照组(P<0.01),D-D水平在发病后12h呈升高趋势;血浆TpP在发病6h内水平达到高峰,后随发病时间浓度递减;Hcy在监测的48h内一直处于较高水平。结论:血浆TpP、Hcy水平升高是引发脑血栓的重要因素,是ACI早期检测的可靠指标,而D-D水平的升高说明脑梗死患者的继发纤溶亢进,在凝血系统激活的同时,纤溶系统也被激活。同时检测TpP、Hcy对脑梗死疾病的早期诊断及防治有重要价值。Objective To study the clinical application value of determination of serum Hey and TpP levels for early diagnosis of cerebral infarction. Methods Serum Hey, TpP （with ELISA） and D -Dimer （with latex agglutination tubidity method） concentrations were determined dynamically （within 6h after onset, 6 - 12h, 12 - 24h, 24 -48h） in 64 patients with acute cerebral infarction and once in 60 controls. Results At admission, the serum contents of all these parameters in the patients were significantly higher than those in the controls （ P 〈 0.01 ）. D - Dimer concentrations began to rise further after 12h. TpP concentrations were highest at admission （ within 6h） and gradually decreased. Hcy concentrations were stable during the studying period （ up to 48hr）. Conclusion Serum TpP and Hcy concentrations increased very early after cerebral infarction （within 6hr） and might be used as early diagnostic markers. Gradually elevated D - Dimer concentrations might reflect secondary fibrinolytie activity.

关 键 词：脑梗死 同型半胱氨酸 血栓前体蛋白 

分 类 号：R581.1[医药卫生—内分泌] R541.4[医药卫生—内科学]