Cys C在肾移植后急性排斥反应诊断中的价值  

The Value of Cystatin(Cys C) in the Diagnosis of Acute Rejection After Renal Transplantation

作　　者：彭志国[1] 田军[1] 周士明[2] 崔先泉[1] 

机构地区：[1]山东大学齐鲁医院血液净化肾移植科,山东济南250012 [2]山东省聊城市人民医院泌尿外科,山东聊城252600

出　　处：《医学与哲学（B）》2009年第2期23-25,共3页Medicine & Philosophy(B)

摘　　要：探讨CysC在肾移植术后诊断急性排斥反应中的价值。63例肾移植患者分为肾功能稳定组(49例)和排斥组(14例),选10例单纯感染患者为对照组,检测CysC值,并与正常对照组(60例)比较。术后监测稳定组和排斥组CysC、BUN、SCr及CCr,对排斥组排斥前后CysC浓度变化以及CysC与SCr、CCr关系进行分析。结果为排斥组排斥前与排斥时CysC浓度差异有统计学意义(P<0.01);CCr在稳定组和排斥组与SCr、CysC均呈直线相关;感染组CysC与正常对照组差异无统计学意义(P>0.05)。说明CysC可以用于肾移植术后急性排斥反应的早期诊断及与单纯感染鉴别诊断。To discuss the value of Cystatin（Cys C） in the diagnosis of acute rejection, 63 cases of renal transplant patients were divided into stable renal function group /49 cases） and the rejection group 114 cases）. Also selected 10 cases with infection as infection control group,checked the concentration of Cys C and compared with the normal control group （60 cases）. Postoperative monitoring the concentration of Cys C, blood urea nitrogen（BUN）, Serum creatinine （SCr） and the endogenous ereatinine clearance rate （CCr）in both groups. When rejection occurred, compared the value detected with before rejection occurred. Analysis of the linear correlation between Cys C, SCr and CCr. Results showed there were statisti- cally significant difference（P〈0.01）of Cys C concentration in rejection group and pre-rejection group. Scr and Cys C showed linear correlation with CCr in stable group and rejection group. There was no statistically significance between the 10 patients with infection were detected the Cys C concentrations and the normal controls （P〉0.05）. Therefore, Cys C can be used in the early diagnosis of acute rejection and antidiastole with infection.

关 键 词：肾移植 排斥反应 半胱氨酸蛋白酶抑制剂C 

分 类 号：R699.2[医药卫生—泌尿科学]