猪腹部火器伤肠管穿透后心肌损伤的变化  

Changes of myocardial injury following intestinal perforation due to abdominal firearm wound in pigs

作　　者：薛会朝[1,2] 冯德元[2] 刘江伟[2] 李崎[1,2] 李建英[2] 张东[2] 邹赛英[2] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]兰州军区乌鲁木齐总医院,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2009年第4期655-657,共3页Progress in Modern Biomedicine

基　　金：兰州军区医药卫生科研基金资助项目(LXH-2005019)

摘　　要：目的:观察腹部火器伤肠管穿透后心肌损伤的变化。方法:健康长白仔猪42头随机分为对照组以及伤后1h、2h、4h、8h、12h和24h组。实验组建立腹部火器伤肠管穿透模型后,分别测定伤后1 h、2h、4h、8h、12h和24h组各组动物血清中LDH、CK、CK-MB水平,并与对照组比较,观察实验组各时间点心脏组织学变化?结果:伤后各组血清LDH、CK、CK-MB水平均高于对照组。伤后8h、12h、24h组光镜下出现逐渐加重的心肌细胞水肿、变性;电镜下4h、8h、12h、24h组出现逐渐的线粒体肿胀、溶解;对照组光、电镜下未见明显的损伤性变化。结论:腹部火器伤肠管穿透导致心肌形态和酶的损伤性变化,随着伤后时间的延长而加重。Objective： To investigate the changes of myocardial injury in abdominal firearm wound pigs. Methods： A total of 42 Chang-Bai piglets were randomized into 7 groups： control group, lh group, 2h group, 4h group, 8h group, 12h group and 24h group. The model of penetrating abdominal firearm wound was established in wounded groups. Serum CK, CK-MB, LDH levels were determined. The histological change of cardiac tissue were observed with light microscope and electron microscope （EMS）. Results： Levels of serum CK, CK-MB and LDH were significantly elevated compared with control group. The experimental groups of8h, 12h, 24h appeared grad- ually aggravated cardiac cells edema and degeneration under light microscope. Mitochondria appeared gradually aggravated swelling and dissolved under EMS in 4h, 8h, 12h, 24h group. There were no obvious injury in the control group under light microscope and EMS. Conclusion： Intestinal perforations due to abdominal firearm wound evoke cardiac enzymes and cause morphological injury to the cardiac muscle, and the injury aggravates with prolongation of wound.

关 键 词：腹部损伤 火器伤 心脏 猪 

分 类 号：R654.2[医药卫生—外科学]