基质金属蛋白酶MMP-2及其抑制物TIMP-2在子宫腺肌病中的表达  

Expressions of Matrix Metalloproteinase-2 and Tissue Inhibitors of Matrix Metalloproteinases-2 in Adenomyosis

作　　者：肖玢 魏鸿麟 

机构地区：[1]哈尔滨市红十字中心医院妇产三科,黑龙江哈尔滨150076

出　　处：《现代生物医学进展》2009年第4期699-700,F0003,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨基质金属蛋白酶MMP-2及其抑制物TIMP-2在子宫腺肌病异位内膜细胞及在位内膜细胞中的表达。方法:应用免疫组化方法(SP法)检测MMP-2及其抑制物TIMP-2在46例子宫腺肌病异位内膜细胞,在位内膜细胞及30例子宫肌瘤内膜细胞的表达。结果:MMP-2蛋白在子宫肌瘤内膜细胞组中阳性表达率为33.33%,在子宫腺肌病异位内膜细胞组中阳性率为89.13%,在位内膜细胞中阳性率为84.78%,差异具有显著性(P<0.01)。TIMP-2蛋白在子宫肌瘤内膜细胞组中阳性表达率为46.67%,在子宫腺肌病异位内膜细胞组中阳性率为15.22%,在位内膜细胞中为47.83%,差异有显著性(P<0.01)。结论:子宫腺肌病患者异位内膜组织中MMP-2表达增高,TIMP-2表达降低,使MMP-2与TIMP-2平衡失调,从而参与了子宫腺肌病的发生发展。Objective： To investigate the significance of MMP-2 and TIMP-2 in the occurrence and development of adenomyosis. Methods： The method of immunohistochemistry was applied to detect the expressions of MMP-2 and TIMP-2 respectively in 46 cases with ectopic endometrium, and eutopic endometrium, and 30 cases with uterine myoma endometrium. Results： The positive expression rate of MMP-2 was 33.33% in uterine myoma endometrium, 89.13% in ectopic endometrium and 84.78% in eutopic endometrium （P〈0. 01）. The positive expression rates of TIMP-2 were as follows： 46.67% in uterine myoma endometrium, 15.22% in ectopic endometrium, and 47.83% in eutopic endometrium （P〈0.01）. Conclusions： The increased expression of MMP-2 and the decreased expression of TIMP-2 in the ectopic endometriosis tissue may lead to the imbalance of the MMP-2 and TIMP-2, resulting in their participating the occurrence and development of adenomyosis.

关 键 词：子宫腺肌病 基质金属蛋白酶 金属蛋白酶抑制物 免疫组化 在位内膜决定论 

分 类 号：R711.7[医药卫生—妇产科学]