含链毒素和含乙胺丁醇方案的对比研究  

Comparative study on efficacy of regimens including streptomycin or ethambutol

作　　者：李群辉[1] 肖成志[1] 宋文虎[1] 端木宏谨[1] 

机构地区：[1]北京卫生部结核病控制中心

出　　处：《中华结核和呼吸杂志》1998年第2期76-78,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：世界银行贷款中国结核病控制项目联合科研管理委员会资助

摘　　要：目的探讨２Ｅ３Ｈ３Ｒ３Ｚ３／４Ｈ３Ｒ３（简称含ＥＭＢ方案）和２Ｓ３Ｈ３Ｒ３Ｚ３／４Ｈ３Ｒ３（简称含ＳＭ方案）在结核病控制工作中的利弊。方法以河北省石家庄市为研究现场，采用回顾、现况和前瞻性研究方法。结果含ＳＭ和含ＥＭＢ方案在疗效、复发率和全程督导上无显著性差异；含ＥＭＢ方案适用性高于含ＳＭ方案；ＳＭ的副作用明显高于ＥＭＢ；链霉素皮试阳性率为４．５％；使用ＳＭ费用高于使用ＥＭＢ８４％；基层消毒合格率为４２．９％，ＳＭ注射不安全；患者更愿意接受含ＥＭＢ方案。结论含ＥＭＢ方案比含ＳＭ方案更适宜于在结核病控制规划中推行。Objective To evaluate the advantages and disadvantages of regimens of 2E 3H 3R 3Z 3/4H 3R 3 (EMB regimen) and 2S 3H 3R 3Z 3/4H 3R 3 (SM regimen) in tuberculosis control program. Method Retrospective, cross sectional and prospective studies were carried out in Shijiazhuang city, Hebei province from January 1994 to June 1996. Result There was no significant difference between the two regimens in efficacy, relapse rate and full course supervision. The EMB regimen was found more applicable than the SM regimen, and the SM regimen caused more side effects than the EMB regimen. Streptomycin skin test had a 4.5% positive rate, and using SM costs 84% more than using EMB. One of the drawbacks found in the SM regimen was that only in 42.9% of the rural sanitation units the disinfection standard could be fulfilled, and the patients preferred the EMB regimen to the SM regimen. Conclusion The EMB regimen is more applicable than the SM regimen in the tuberculosis control program.

关 键 词：结核.肺 药物疗法 链霉素 乙胺丁醇 

分 类 号：R521.05[医药卫生—内科学]