基于体素的形态测量学方法用于创伤后应激障碍病人脑结构的研究  

Voxel Based Morphometric Study of Brain Structure in Patients with Posttraumatic Stress Disorder

作　　者：杨春兰[1] 吴水才[1] 白燕萍[1] 侯彩兰[2] 高宏建[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100022 [2]中南大学湘雅二医院精神卫生研究所,长沙410011

出　　处：《生物医学工程学杂志》2009年第1期30-33,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30470621);北京市自然科学基金资助项目(3072004)

摘　　要：采用基于体素的形态测量学(Voxel based morphometry,VBM)方法来研究创伤后应激障碍(Post traumatic stress disorder,PTSD)病人和正常人脑结构的差异。传统的VBM方法用来检测两组被试脑灰质或者脑白质密度的差异;优化的VBM方法则可以用来测量灰质或者白质局部体积的差异。实验结果表明,PTSD病人右侧额叶、额中回、右侧小脑蚓部、左侧尾状核、顶叶等部位灰质密度或者体积明显增高,左侧额叶、额中回灰质密度降低;而白质无明显差异。这些差异与功能影像的研究取得了一致的结果,从而为进一步研究PTSD病因提供了脑结构影像依据。同时,实验结果也验证了VBM方法在检测脑结构差异问题中的有效性。Voxel based morphometry （VBM） methods are used to detect the difference in brain structures be- tween the posttraumatic stress disorder （PTSD） sufferers and the normal controls. Standard VBM method can detect the difference of the gray matter or white matter densities while the optimized VBM method can detect the difference of gray matter or white matter volumes in the whole brain. The experiments showed that for the patient group, gray matter density or volumes significantly increased in the right frontal lobe, middle frontal gyrus, vermis, left caudate and parietal lobe, compared with the normal controls. However, in the left frontal lobe and middle frontal gyrus, gray matter density significantly decreased. There is no significant difference in white matter between the two groups. These results are consistent with those of the fMRI, which not only provide the evidence for further study of the pathogeny in PTSD but also validate the efficiency of the VBM methods for detecting the difference in the whole brain structure.

关 键 词：创伤后应激障碍脑结构 基于体素的形态测量学 空间标准化 

分 类 号：R318.04[医药卫生—生物医学工程] TP391.41[医药卫生—基础医学]