动脉粥样硬化大鼠的主动脉血管生物力学分析  

Analysis on Mechanical Properties of Aortic Artery in Rats with Atherosclerosis

作　　者：陈明[1] 刘盛林[1] 戴峥 汪毅 刘怡[1] 余源 

机构地区：[1]同济大学附属东方医院心脏中心,上海200120 [2]昆明市延安医院心胸外科研究中心,昆明650051

出　　处：《生物医学工程学杂志》2009年第1期89-92,共4页Journal of Biomedical Engineering

基　　金：昆明市重点实验室基金资助项目(昆科社字2003-011)

摘　　要：对动脉粥样硬化(AS)大鼠的主动脉进行血管生物力学研究,以了解AS所导致的主动脉血管生物力学特性。建立大鼠AS动物模型,测量离体主动脉血管零应力状态展开角,进行血管生物力学载荷试验,以获得压力-应力关系的数据,对AS组大鼠主动脉电镜标本,作组织纤维含量百分率测定,分析力学参数与组织纤维含量的关系。研究结果显示(1)AS大鼠的零状态展开角明显小于对照组(87.74°±9.67°vs 196.03°±27.76°,P<0.001);(2)主动脉在长轴、短轴方向的应变物质常数α0、α1、α2及b0、b1、b2的绝对值均明显低于对照组(P<0.05～0.001);(3)AS组大鼠主动脉纤维组织百分率与物质常数a值及b值各参数之间具有良好的相关性(r值在-0.7523～-0.8423之间,P<0.001)。本研究提示AS主动脉病理重构与力学性重构之间存在密切的联系。To understand the mechanical properties of aortic artery of atherosclerosis（AS）, the aortic artery of rat with AS was studied by mechanical test. Wistar rats were used for establishing the model. The mechanical measurements of opening angle in zero-stress state and the vessel loading test were conducted on the isolated aortic arteries of AS rats. Data on the stress-strain of aortic artery were obtained. Determination of percentage of collagen content was made with the use of electron microscope. The relationship between mechanical measurements and collagen con- centration was evaluated. The opening angle in the group of AS was significantly smaller than that in control（87.74°±9.67° vs 196.03°±27.76°,P〈0. 001）. Significant decrease of material constants（a0, a1, a2, b0, bl, b2 ） in both long axis and radial axis was observed in AS group（campared with control, P〈0.05-0. 001）. Close relationship be- tween the mechanical constants and the percentage of elasdn and collagen content was observed（r=- 0. 7523 to - 0. 8423, P〈0. 001）. In conclusion, mechanical remodeling in aortic artery of AS might be related with histological remodeling.

关 键 词：动脉粥样硬化 零应力状态 应力-应变 主动脉 

分 类 号：R318.01[医药卫生—生物医学工程] R541.4[医药卫生—基础医学]