超声药物促渗设备的研制  

Design of Transdermal Ultrasonophoresis Equipment

作　　者：李良成[1] 张永顺[1] 李忠红[1] 

机构地区：[1]白求恩军医学院医学影像教研室,石家庄050081

出　　处：《生物医学工程学杂志》2009年第1期184-186,共3页Journal of Biomedical Engineering

摘　　要：随着生物技术的快速发展,大量生物制剂进入临床,经皮给药是将药物贴敷在皮肤表面,依靠扩散使药物穿过皮肤进入皮下毛细血管。但大多数药物在皮肤角质层屏障作用下难以渗入皮下,需要用物理和化学的辅助方法促进药物渗透。超声经皮给药促渗技术能够提供数倍于常规给药方法的持续稳定的渗透率,是一种极具潜力的给药方式。本文介绍一种基于MSP430单片机的低频超声经皮给药渗透系统的设计原理、硬件结构及其功能。The recent fast development in biotechnology has resulted in a large number of therapeutic biologicals coming in the foreground for clinical application. Transdermal drug delivery （TDD） is designed for patching the drug on the skin, and then the drug molecules permeate through the skin into the subcutaneous capillary vessels. Howev- er, very few drugs can be administered transdermally at the therapeutic levels to pass through the barrier of stratum corneum. Several physical and chemical methods are applied to improve the permeability of skin. Research result shows that the low-frequency ultrasonic technique can extraordinarily increase the rate of permeation. As a result, it is becoming one of the potential methods that serve as the substitutes for traditional methods. In this paper is presen- ted a type of equipment based on MSP430. The principle of design, the structure of hardware, and the applied function in this area are described.

关 键 词：超声 经皮给药 单片机 

分 类 号：TH789[机械工程—仪器科学与技术]