积雪草总苷元抗抑郁作用的研究  

The Effects on Anti-depression of Centella Triterpenic Genine

作　　者：曹尉尉[1] 李晏[1] 伊佳[2] 

机构地区：[1]中国人民解放军四一一医院药械科,上海200081 [2]第二军医大学药学院,上海200433

出　　处：《中国现代应用药学》2009年第2期92-95,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：上海市自然科学基金(064119608)

摘　　要：目的探讨积雪草总苷元的抗抑郁作用及其可能作用机制。方法采用大鼠强迫游泳实验,抑制单胺重摄取作用实验等动物模型来考察积雪草总苷元抗抑郁作用及其可能作用机制。结果积雪草总苷元能够显著缩短大鼠游泳不动时间;对单胺类递质去甲肾上腺素(NE)、多巴胺(DA)重摄取抑制作用不明显,但是显著增加5-羟色氨酸致小鼠甩头作用。结论积雪草总苷元有抗抑郁活性,可能与其增加5-羟色胺(5-HT)能神经系统有关。OBJECTIVE To investigate the anti-depressed effects of Centella triterpenie genines and to explore its possible mechanism . METHODS Rat foree-swim model test were used to observe the effect of Centella triterpenic genines on relieving depression. The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters. RESULTS Centella triterpenic genines dramatically reduced the immobility time in the forced swim test of rats. Centella triterpenic genines had no obvious inhibition from reuptake of monoamine neurotransmitters of noradrenalin and dopamine, but eould distinctly increased the frequency of head- twitch in the 5-hydroxytryptophan （5-HTP） induced head-twitches test. CONCLUSION Centella tfiterpenic genines has antidepressant effeets,and its mechanism may be related to the reinforcement of 5-hydroxytrypamine（5-HT）nerves system.

关 键 词：积雪草总苷元 抑郁 应激 

分 类 号：R964[医药卫生—药理学]