小脑损伤患者的时间知觉  

Time perception in patients with cerebellar lesion

作　　者：刘平[1] 徐培坤[2] 汪凯[1] 程怀东[1] 蒋玉宝[1] 牛朝诗[3] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]安徽医科大学第一附属医院神经外科,合肥230022 [3]安徽省立医院神经外科

出　　处：《中华神经科杂志》2009年第2期87-90,共4页Chinese Journal of Neurology

基　　金：基金项目：国家自然科学基金资助项目（30670706）;“973”项目子课题（2005CB522800）

摘　　要：目的通过对小脑损伤患者时间知觉的研究，了解小脑参与时间感知加工的可能机制。方法采用时距复制任务，对26例小脑损伤患者和在年龄、利手及受教育程度上相匹配的26名健康对照者的时间知觉能力进行研究。试验包括持续呈现的视觉目标形式的3段标准时间（600ms、3和5s），呈现结束后，延迟1或5s进行复制。结果小脑损伤组与健康对照组均对600ms有高估，而对3和5s有低估；与健康对照组比较，小脑损伤患者对600ms时距复制[延迟时间为1和5s的复制结果（s）分别为1．37±0．24、1．26±0．29]结果的差异均有统计学意义（Z=-5．347、-4．230，均P〈0．01），而对3和5s的时距复制结果（延迟时间为1和5s）均无统计学意义（Z=-1．200、-0．092、-1．519、-0．723，均P〉0．05）。结论小脑损伤患者对瞬时时间的感知明显受损，而对长时间的感知无损伤，提示小脑可能特异性地参与了毫秒时间感知的认知加工。Objective To explore further the abilities of cerebellar lesions in skills of time estimation, and to test the hypothesis that cerebellum is involved in the special network of time perception. Methods Time reproduction was required for 3 time intervals of 600-milliseconds, 3 and 5 seconds with visual discrimination for control. Participants reproduce those time intervals after 1-second or 5- seconds of delay. Twenty-six patients with cerebellar lesions were compared to 26 healthy controls, matched for age, handedness, education. Results 600-milliseconds was overestimated by both cerebellar lesions and healthy controls, however, both 3-seconds and 5-seconds were underestimated. Patients with cerebellar lesions were significantly impaired on 600-milliseconds reproduction task （ delaying 1 s or 5 s, 1.37 ± 0. 24, 1.26 ±0. 29 respectively, Z = -5. 347, -4. 230, both P 〈0. 01）. No group differences were found for the 3-seconds and 5-seconds time reproduction （ delaying 1 s or 5 s, Z = - 1. 200, - 0. 092, - 1. 519, - 0. 723, all P 〉 0. 05）. Conclusion The findings suggest that patients with cerebellar lesions perform poorly during measurement of the shorter interval, but show no impairment of longer intervals perception, supporting the hypotheses that cerebellum is specifically involved in the perception of sub-second intervals.

关 键 词：时间知觉 小脑疾病 神经心理学测验 

分 类 号：R686[医药卫生—骨科学]