EA204对兔离体主动脉的影响  

The Effect of an Estrone Derivate EA204 on Isolated Thoracic Aorta in Rabbits

作　　者：李娟[1] 付守廷[2] 李辉[3] 陈国良[4] 王锐[1] 姚遥[1] 

机构地区：[1]宁夏医科大学基础学院,银川750004 [2]沈阳药科大学药学院,沈阳110016 [3]大理学院药学院,大理671000 [4]沈阳药科大学制药工程学院,沈阳110016

出　　处：《宁夏医科大学学报》2009年第1期19-21,共3页Journal of Ningxia Medical University

基　　金：宁夏医科大学面上项目(XM200710)

摘　　要：目的研究雌酚酮衍生物EA204对兔离体主动脉的作用及其作用机制。方法兔主动脉环离体实验。结果EA204（10^-5～3×10^-3mol／L）可以剂量依赖性地抑制氯化钡、氯化钾、去甲肾上腺素引起的兔离体主动脉环的收缩。兔离体主动脉环经亚甲基蓝或吲哚美辛预处理后，分别可使10^-5～10^-4或10^-43×10^-3mol／L EA204的舒张作用受抑制；经普萘洛尔预处理后，对EA204（10^-5～3×10^-3mol／L）的舒张作用无影响。结论EA204舒张兔离体主动脉的作用与NO—cGMP途径及前列腺素合成酶途径有关。Objective To explore the relaxing effect and its mechanism of an estrone derivate EA204 on isolated thoracic aorta ring in rabbits. Methods Experiments on isolated thoracic aorta ring were administered in rabbits. Results EA204（10^-5 -3 × 10^-3moL/L） had a concentration-dependent relaxing effect on isolated thoracic aorta ring of rabbits pre-contracted with BaCl, KCl or NE. After incubation with Methylene Blue, the relaxing effect on isolated thoracic aorta ring of rabbits of EA204 （10^-5 - 10^-4 mol/L） was significantly inhibited. After incubation with Indomethacin, the relaxing effect of EA204 （ 10^- 4 - 3 × 10^- 3 mol/L） was significantly inhibited. After incubation with Inderal,the relaxing effect of EA204 （ 10^-5- 3 ^ 10^-3 mol/L） had no change. Conclusion EA204 can relax isolated thoracic aorta in rabbits. The mechanism was possibly associated with the NO-cGMP and prostaglandin synthetase pathway.

关 键 词：雌酚酮 兔 主动脉 阻断剂 

分 类 号：R961[医药卫生—药理学] R962[医药卫生—药学]