老年人红细胞膜唾液酸含量与红细胞免疫功能的相关性  

The correlation between erythrocyte membrance sialic acid and immune function in the aged patients

作　　者：刘希英[1] 黄振学[1] 赵秀珍[1] 段建华[1] 张超英[1] 

机构地区：[1]青岛医学院微生物学教研室

出　　处：《中华老年医学杂志》1998年第2期110-112,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨老年人红细胞膜唾液酸（ＲＢＣｍ－ＳＡ）与红细胞免疫功能的相关性。方法采用Ｂｉａｌｓｃｈｅ试剂法检测ＲＢＣｍ－ＳＡ，Ｆ－８８３６化学比色法检测血浆唾液酸（Ｐ－ＳＡ），红细胞免疫粘附试验观察红细胞Ｃ３ｂ受体花环率（ＲＲＣＦ）。结果老年急性心肌梗死（ＡＭＩ）组和脑梗塞（ＡＣＩ）组的ＲＢＣｍ－ＳＡ分别为３０．８±４．３和３１．３±４．４μｇＮＡＮＡ／ｍｇ膜蛋白，ＲＲＣＦ分别为１６．７％±３．５％和１６．０％±３．６％，均低于老年对照组（Ｐ＜０．０１或０．０５），老年对照组均低于非老年对照组（均为Ｐ＜０．０５）；ＡＭＩ和ＡＣＩ患者的Ｐ－ＳＡ分别为２．４±０．４和２．４±０．３ｍｍｏｌ／Ｌ，均高于老年对照组（均为Ｐ＜０．０５），老年对照组则高于非老年对照组（Ｐ＜０．０５）。老年患者和老年对照组的ＲＢＣｍ－ＳＡ与ＲＲＣＦ均呈正相关，而ＲＢＣｍ－ＳＡ与Ｐ－ＳＡ均呈负相关。结论老年人红细胞Ｃ３ｂ受体花环率降低与ＲＢＣｍ－ＳＡ代谢障碍有关。Objective To study correlation between red blood cell membrance sialic acid (RBCmSA) and RBC immune function in aged people. Methods Bialsche reagent test was used to determine RBCmSA. F8836 chemical colorimetric method was for estimating plasma sialic acid (PSA). RBC immune adherence test was for studying the rate of RBCC3b receptor rosette formation (RRCF). Results RBCmSA in the aged acute myocardial infarction (AMI) group and acute cerebral infarction (ACI) group was 308±43 and 313±44μg NANA/mg membrance protein , respectively and both were significantly lower than that in the aged control, RRCF in the aged AMI and ACI was 167%±35% and 160%±36%, respectively and both were also significantly lower than in the aged control (P<001 or 005); RBCmSA and RRCF in the aged control were lower than in the nonaged control (P<005); PSA in the aged AMI and ACI was 24±04 and 24±03mmol/L respectively and both were significantly higher than that in the aged conrtol (P<005) ; PSA in the aged control was significantly higher in comparison in the nonaged control (P<005). Positive correlation was found between RBCmSA and RRCF in both the aged patients and the aged control(P<005). Negative correlation showed between RBCmSA and PSA in both the aged patients and the aged control(P<005). Conclusions The decrease of RRCF in aged people is related to the metabolic disturbance of RBCmSA.

关 键 词：心肌梗塞 唾液酸类 红细胞免疫学 

分 类 号：R542.220.3[医药卫生—心血管疾病] R392.12[医药卫生—内科学]