抗磷脂抗体与急性冠脉综合征相关性研究  

Research on the Correlation Between Anti-phospholipid Antibodies and Acute Coronary Syndrome

作　　者：彭文华[1] 王勇[2] 谢瑶[2] 张荣富[2] 

机构地区：[1]北京协和医学院研究生院,北京100029 [2]卫生部中日友好医院

出　　处：《内科急危重症杂志》2009年第1期14-16,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:初步探讨抗磷脂抗体与急性冠脉综合征(ACS)的相关性。方法:应用酶联免疫吸附法检测55例ACS患者、23例稳定型心绞痛及陈旧性心肌梗死的患者和24例门诊体检人员血清中抗心磷脂抗体IgG,IgM亚型和抗β2糖蛋白ⅠIgAGM,IgA,IgG,IgM亚型抗体的水平。结果:ACS组中抗磷脂抗体阳性率为54.3%,其中抗心磷脂抗体阳性率为17.5%,抗β2糖蛋白I抗体阳性率为36.8%。ACS组中抗心磷脂抗体IgG亚型、抗β2糖蛋白ⅠIgAGM亚型及IgM亚型抗体的阳性率和滴度明显升高,尤其在急性心肌梗死患者中这3种抗体阳性率均显著高于对照组。另外,抗β2GPI抗体阳性的冠心病患者血脂水平(尤其是血清总甘油三酯)高于抗磷脂抗体阴性的冠心病患者血脂水平。结论:ACS的发病可能与抗磷脂抗体有关,尤以急性心肌梗死相关性明显,抗磷脂抗体可能参与ACS血管病变的发病过程。Objective： To investigate the correlation between the anti-phospholipid antibodies and acute coronary syndrome （ACS）. Methods： Fifty-five patients with ACS, 23 patients with stable angina and myocardial infarction, and 24 healthy people were involved in the study. Anticardiolipin IgG, IgM and anti β2 glycoprotein I IgAGM, IgA, IgG, IgM were detected by the method of ELISA. Results： A significant elevation of anti-phospholipid antibodies （54. 3%） in patients with ACS was observed. The frequency of anticardiolipin and anti-β2 glycoprotein I antibodies were 17. 5%and 36. 8% respectively. Levels of ACA-IgG, anti-β2 GPI IgAGM, anti-β2 GPI IgM were obviously elevated in patients with ACS especially in patients with AMI. Total triglyceride was higher in patients with coronary artery disease with positive anti-β2 glycoprotein I antibodies than that with negative hnti-phospholipid antibodies. Conclusion： Anti-phospholipid antibodies seem to behave as risk factors for ACS especially myocardial infarction, which may contribute to the process of vascular disease in patients with ACS.

关 键 词：急性冠脉综合征 抗心磷脂抗体 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]