抑郁发作患者与正常人血浆孤啡肽含量的对照研究  

A Control Study of Orphanin FQ in Patients with Depression and Health Adults

作　　者：王丽娜[1] 刘兰芬[2] 张敬悬[2] 赵贵芳[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]山东省精神卫生中心,山东济南250014

出　　处：《中国临床心理学杂志》2009年第1期48-50,共3页Chinese Journal of Clinical Psychology

基　　金：山东省卫生厅科研基金资助项目(2005HW115)

摘　　要：目的:探讨抑郁发作患者血浆孤啡肽(OFQ)水平的变化,为抑郁发作的起病、诊断、治疗等寻找新的生物学指标。方法:筛选45例抑郁发作患者和31例正常人,应用放射免疫(RIA)法分别测定其血浆OFQ浓度,比较抑郁组与对照组血浆OFQ水平,抑郁组OFQ含量与各量表总分的相关性,分析相关的影响因素。结果:①抑郁组血浆OFQ水平显著高于对照组(t=4.65,P<0.01)。②抑郁组OFQ含量与HAMD、MADRS、HAMA总分均呈显著正相关。③血浆OFQ含量的影响因素主要有家人的关心、睡眠状况、家庭和睦、自杀观念或未遂史和总病程。结论:血浆OFQ水平的变化可能与抑郁发作的发病机制相关并反映疾病的严重程度。Objective： To investigate the changes of plasma orphanin FQ （OFQ） level in patients with bipolar and unipolar depression. Methods： 45 patients with depression and 31 health adults were studied. The concentrations of plasma OFQ were measured by radioimmunoassay （RIA）. Results： （1）Compared with the healthy controls, the level of plasma OFQ was significantly higher in patients with depression （t=4.65 ,P〈0.01）. （2）The plasma OFQ level was positively correlated to HAMD, MADRS and HAMA. （3）Many factors affected the level of plasma OFQ, including insomnia, family relationship, history of suicide, etc. Conclusion： The changes of plasma OFQ level may play a role in the pathogenesis of depression and reflect the severity of disease.

关 键 词：抑郁发作 孤啡肽 

分 类 号：R395.2[哲学宗教—心理学]