Th1/Th2细胞平衡偏移与自身免疫性甲状腺疾病的相关性研究  

The relationship between the imbalance of the Th1/Th2 cytokines and autoimmune thyroid disease.

作　　者：沈浩[1] 胡玲[1] 

机构地区：[1]南昌大学第三附属医院内分泌科,南昌330006

出　　处：《中国实用内科杂志》2009年第3期252-253,共2页Chinese Journal of Practical Internal Medicine

基　　金：江西省卫生厅学术带头人资助项目

摘　　要：目的明确白细胞介素-2(IL-2)、IL-5与自身免疫性甲状腺疾病(AITD)发生的相关性,探讨Th1/Th2细胞平衡在自身免疫性甲状腺疾病发病中的作用。方法选取2007年8月至2008年5月南昌大学第三附属医院内分泌科45例Graves病(GD)、30例桥本甲状腺炎(HT)患者,同时选取20名健康体检者作为对照组。采用酶联免疫吸附试验法(ELISA)检测患者和对照组血清中Th1型细胞因子IL-2和Th2型细胞因子IL-5并进行统计学分析。结果(1)GD患者血清中IL-5明显高于HT组和对照组(P<0.05),而IL-2与对照组相比差异无统计学意义(P>0.05)。(2)HT患者血清IL-2明显高于GD组和对照组(P<0.05),而IL-5与对照组相比差异无统计学意义(P>0.05)。(3)HT患者Th1型细胞因子IL-2与甲状腺球蛋白抗体(TGAb)和甲状腺微粒体抗体(TMAb)呈显著正相关(r=0.517,P<0.05;r=0.475,P<0.01)。结论Th1/Th2细胞免疫平衡在HT患者中以Th1细胞免疫占优势为主,在GD患者中以Th2细胞免疫占优势为主。Objective To analysis the serum levels of the Th1/Th2 cytokines interleukine-2 and interleukine-5 in patients with autoimmune thyroid disease （AITD） and investigate the relationship between the imbalance of Th1/Th2 cytokines and the pathogenesis of AITD. Methods 20 healthy as controls and 75 patients were studied. 45 patients suffered from GD, 30 patients suffered from HT. The serum concentrations of interleukine-2 （IL-2） and interleukin-5 （IL-5）, representa- tive cytokines of Th1 and Th2 cells respectively, were assayed by enzyme-linked immunosorbent assay （ELISA）. Results （ 1 ） Compared with HT group and controls, the concentration of IL-5 in GD group was remarkably increased （ P 〈 0. 05 ）. （ 2 ） Compared with GD group and controls, the concentration of IL-2 in HT group was remarkably increased （ P 〈 0. 05）. （3）In HT patients,IL-2 serum levels were positively associated with TGAb and TMAb（r =0. 517 ,P 〈0. 05 ;r = 0. 475 ,P 〈 0. 01 ）. Conclusion The expression of Th1 type cytokines gains advantage in HT, and the expression of Th2 type cytokines gains advantage in GD.

关 键 词：细胞因子 TH1/TH2 自身免疫性甲状腺疾病 

分 类 号：R5[医药卫生—内科学]