急性脑外伤大鼠脑神经节苷脂含量的研究  

Studies of gangliosides in the rat brain with acute cerebral trauma

作　　者：张卫宁[1,2] 王江雁 王仁杰 许玉茹 王梦寅[1,2] 

机构地区：[1]解放军白求恩国际和平医院神经外科 [2]解放军石家庄高等医学专科学校生化教研室

出　　处：《中华神经外科杂志》1998年第1期13-15,共3页Chinese Journal of Neurosurgery

摘　　要：目的：研究急性脑外伤后大鼠脑神经节苷脂含量的变化。方法：选取Ｗｉｓｔａｒ大鼠３６只，落体撞击法造成左顶脑挫裂伤，于伤后４、１２和２４小时测定脂结合唾液酸含量和神经节苷脂组分的相对百分比值变化。结果：急性脑外伤后大鼠脑组织中脂结合唾液酸含量随时间呈明显下降趋势。神经节苷脂组分的变化以ＧＤ３的持续下降及ＧＭ１的增加最为显著，而且受损２４小时后除ＧＤ１ａ外其余几种神经节苷脂含量均较受损１２小时后有显著降低。结论：急性脑外伤后脑内有自我调节机制来增加ＧＭ１的合成，但是这种自我调节是有限的，因此，建议早期使用神经节苷脂治疗急性脑外伤。Objective: To study the changes of gangliosides in the rat brain after the acute cerebral trauma. Method: Cerebral contusion were made in 36 Wistar rats by dropping weight method. Ganglioside content and the indivival relative percentage of GM1, GD1a,CD1b and GT1b in the brain were measured 4h, 12h and 24h following injury. Result: The content of LBSA decreased significantly after the acute cerebral trauma. The indivival relative percentage of GD3 decreased and GM1 increased. GM1, GD3, GD1b and GT1b decreased significantly 24h following injury compared with 12h. Conclusion: The above data assume that there is an autoadjustment to increase GM1, but with limitation. It suggests that the treatment of GM1 should start early.

关 键 词：颅脑损伤 脑外伤 神经节苷脂 

分 类 号：R651.15[医药卫生—外科学]