丹皮酚在清醒大鼠体内的药动学和绝对生物利用度  

Pharmacokinetic Features and Absolute Bioavailability of Paeonol in Conscious Rat

作　　者：马丽焱[1] 缪剑华[2] 许旭东[1] 唐炳兰[2] 张琪[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100094 [2]中国医学科学院药用植物研究所广西分所,广西南宁530023

出　　处：《时珍国医国药》2009年第2期413-414,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的研究丹皮酚不同途径给药后在清醒大鼠体内的药代动力学。方法大鼠分别灌胃(ig)和静脉注射(iv)丹皮酚10 mg/kg,于给药后不同时间采集血样,HPLC法测定血药浓度,DAS 2.0软件计算药动学参数。结果大鼠ig和iv丹皮酚后,AUC0-∞为(18.13±4.78)和(62.70±6.05)mg.L-1.min-1,t1/2 z分别为(23.37±8.73)和(52.01±11.70)min,MRT0-∞分别为(28.07±8.68)和(47.37±7.45)min;ig丹皮酚的Tm ax和绝对生物利用度分别为(5.0±0.00)min和28.92%。结论不同给药途径丹皮酚的体内药代动力学过程不同,丹皮酚口服生物利用度低。Objective To study pharmaeokinetie features of paeonol after intragastrie （ig） and intravenous （ iv ） administration to conscious. Methods Paeonol was administered ig and iv in single dose（ 10 mg/kg）. Blood samples were collected at intervals after each administration. Plasma concentration of paeonol was detected by HPLC. Pharmaeokinetie parameters were calculated by pharmaeokinetie program DAS 2.0 in which noneompartmental model was chosen. Results Pharmaeokinetie parameters for pae- onol following intragastrie and intravenous administration in conscious rat were as follows： AUC0-∞ were（ 18. 13 ± 4.78） and （62.70＋ 6.05）mg·L·min-1. t1/2 were（23.37 ＋8.73）and（52.01 ±1.70）min. MRT0-∞ were （ 28. 07 ±8. 68 ） and （47.37 ± 7.45 ）rain. After intragastrie administration, Tmax and absolute bioavailability were（5.0± 0.0）rain and 28.92%. Conehtsion Pharmaeokinetie processes of paeono] are different after administered ig or iv. Absolute bioavailability of paeonol for ig is low.

关 键 词：丹皮酚 高效液相色谱 药代动力学 给药途径 生物利用度 

分 类 号：R285.5[医药卫生—中药学]