和胃散急性毒性实验研究  

Experimental study on acute toxicity of Hewei Powder

作　　者：毛和平 刘光斌 刘效栓 宋京都[2] 方延学[2] 

机构地区：[1]酒钢医院药学部,甘肃嘉峪关735100 [2]甘肃省药品检验所,甘肃兰州730000

出　　处：《中国医药导报》2009年第6期22-22,34,共2页China Medical Herald

摘　　要：目的:观察和胃散的急性毒性反应。方法:和胃散以最大浓度及最大给药体积的药液灌胃(ig)给药,3次/d。连续观察7d,记录小鼠毒副作用情况。结果:观察7d后,全部动物健存,小鼠体重平均增长24.82%,未见任何毒性作用。计算得和胃散最大给药量为54.0g/kg体重,相当于成人日用量的216倍。结论:本实验提示和胃散毒性较小。Objective： To study the toxic reaction of Hewei Powder in mice. Methods： The maximum administration dosage of Hewei Powder were determined by ig administration in mice, three times a day. Its acute toxic reactions were observed for 7 days. Results： All mice were survived, and no toxic reaction was shown during the observed period. The average rate of its increasing weight was 24.82%. The maximum administration dosage was 54.0 g of Hewei Powder given to mice per kilogram, equivalent to men＇s daily administration dosage by 216 times. Conclusion： Hewei Powder is safe for oral administration.

关 键 词：和胃散 小鼠 急性毒性 

分 类 号：R285.5[医药卫生—中药学]