空肠弯曲菌抗体对正常结肠神经节细胞结合的病理学观察  

Pathological study on the antibody of Campylobacter jejuni to ganglionic cells of colon

作　　者：韩克[1] 李金良[1] 李殿国[1] 孙小兵[1] 张丽[1] 宋磊[2] 

机构地区：[1]山东大学第二医院外科,山东济南250033 [2]山东威海市立医院普外科,山东威海264200

出　　处：《中国现代普通外科进展》2009年第1期29-31,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:通过观察空肠弯曲菌抗体在正常结肠神经节细胞上的结合,初步探讨空肠弯曲菌抗体影响结肠神经节细胞发育,导致神经节细胞变性的可能性。方法:取正常结肠标本60例,随机分为实验组和对照组,免疫组织化学方法处理。实验组利用空肠弯曲菌抗体作用于正常结肠神经节细胞,观察抗体与神经节细胞的结合情况;对照组利用PBS液代替空肠弯曲菌抗体,其他同实验组。比较两组空肠弯曲菌抗体的结合有无不同。结果:空肠弯曲菌抗体可以和正常结肠的神经节细胞结合,结合的阳性率为83.3%。实验组和对照组比较差异有统计学意义(P<0.05)。结论:空肠弯曲菌抗体可与神经节细胞结合,可能影响神经节细胞发育及导致神经节细胞变性。0bjective： To study the effect of the antibody of Campylobacter jejuni in the degeneration of ganglionic cells. Methods： The samples of 60 patients with normal colon were divided into two groups. Immunohistochemistry method was used to check the effect of the antibody of Campylobacteria to the normal ganglionic cells. Results： Brown-yellow granules was found in ganglionic cells of normal colon（about 83.3%）.There was statistical difference between experimental group and comparison group. Conclusions： The antibody of campylobacteria can combine with ganglionic cells and may result in the degeneration of ganglionic cells.

关 键 词：弯曲菌 神经节 肠神经元发育异常 

分 类 号：R726.5[医药卫生—儿科]