低浓度臭氧对小鼠呼吸系统的影响  

Effects of Low Concentration Ozone on the Respiratory System of Mice

作　　者：黎大明[1] 余贵英[1] 宋宏[1] 廉旭[1] 董书芸[1] 

机构地区：[1]中山医科大学环境卫生学教研室

出　　处：《卫生研究》1998年第1期32-34,共3页Journal of Hygiene Research

基　　金：卫生部科研基金

摘　　要：将小鼠暴露于０．１，０．２５和１．０ｍｇ／ｍ３的臭氧环境中。每天８小时，连续３天。电镜下观察小鼠支气管纤毛超微结构变化，并测定了肺组织ＬＰＯ含量和腹腔巨噬细胞吞噬功能。结果表明：０．１ｍｇ／ｍ３组未见明显纤毛损伤；０．２５ｍｇ／ｍ３可见线粒体，内质网高度肿胀，纤毛坏死脱落，１．０ｍｇ／ｍ３亦见纤毛坏死脱落，纤毛稀少。巨噬细胞吞噬功能在０．２５和１ｍｇ／ｍ３组均比对照组低（Ｐ＜０．０１），而肺组织ＬＰＯ含量却无明显变化。Effects of low concentration of O 3 on the respiratory system in mice were studied in the present study. Mice were exposed to 0.1, 0.25 and 1.0mg/m 3 of O 3, respectively for 8h per day for 3 days. Cilia in brochia, Lipid peroxide (LPO) in lung tissue and phagocytic function of macrophage in mice were examined. The results showed that there were cilia damage in the 1.0mg/m 3 group and swelling of mitochondrias as well as endoplasmic reticulums in the 0.25mg/m 3 group. But no damage was found in the group of 0.1mg/m 3. Furthermore, phagocytic rates in the 0.25 and 1.0mg/m 3 groups were significantly lower than that of control group ( P <0.01). No differences in LPO leads were found.

关 键 词：臭氧 小鼠 呼吸系统 低浓度 

分 类 号：X503.1[环境科学与工程—环境工程] R122[医药卫生—环境卫生学]