嘧螨酯的合成与杀螨活性  

Synthesis of Fluacrypyrim and Its Acaricidal Activity

作　　者：刘若霖[1,2] 张金波[2] 李淼[2] 张弘[2] 刘长令[2] 

机构地区：[1]辽宁大学,沈阳110036 [2]沈阳化工研究院,沈阳110021

出　　处：《农药》2009年第3期169-171,共3页Agrochemicals

摘　　要：以氰胺和异丙醇制备异丙氧基脒甲烷磺酸盐,再与三氟乙酰乙酸乙酯反应制得2-异丙氧基-4-羟基-6-三氟甲基嘧啶,最后与(E)-2-[2-(氯甲基)苯基]-3-甲氧基丙烯酸甲酯反应合成目标产物嘧螨酯,其结构经核磁、红外验证。生物活性测定结果表明该化合物具有良好的杀螨活性。Fluacrypyrim was synthesized by reacting （E）-methyl 2-（2-（chtoromethyl）phenyl）-3-methoxyacrylate with 2-isopropoxy-6-（trifluoromethyl）pyrimidin-4-ol prepared from ethyl 4,4,4-trifluoro-3-oxobutanoate and isopropyl carbamimidate methanesulfonate prepared from cyanamide and propan-2-ol, and its structure was confirmed by 1H NMR and IR. The biological test results show that fluacrypyrim has good acaricidal activity.

关 键 词：嘧螨酯 合成 杀螨活性 

分 类 号：TQ454.2[化学工程—农药化工]